In situ forming implant formulations as multi-purpose prevention technologies

Research output: Contribution to conferencePoster

Abstract

In situ forming implant formulations as multi-purpose prevention technologies Clement M. Haeck* 1, Thakur Raghu Raj Singh1, R. Karl Malcolm1
1School of Pharmacy, Queen's University Belfast, Belfast, United Kingdom

Background: There is growing interest in the development of multi-purpose prevention technology (MPT) products for women that
combine contraception with prevention of HIV and/or other sexually transmitted infections. In situ implant-forming subcutaneous (SC) or intramuscular (IM) gels represent a practical formulation option for such MPT products.
Purpose: In situ forming implant (ISFI) gels were formulated and tested to determine concentrations suitable for SC or IM injection. Syringeability testing was conducted to select optimum formulations for ease of expulsion using standard syringes. Impact of polymer type, polymer concentration and expelled volume was investigated.
Methods: ISFI formulations were prepared by dissolving PLGA in N-methyl-2-pyrrolidone (10—30% w/w). Work of syringeability (WoS) and maximum force (MF) of expulsion were investigated using needles of different diameter. A texture analyser was used to expel the formulations from a 1 mL syringe at different rates.
Results: A decrease in the needle diameter resulted in an increase in the WoS and MF exerted on the syringe. WoS and MF increased with increasing polymer concentration, volume of formulation and rate of expulsion.
Conclusion: This study helped to define optimum ISFI formulations. After incorporating a combination of an antiretroviral and a contraceptive drug within these ISFI formulations, we aim to use them to develop injectable MPT products for simultaneous hormonal contraception and HIV prevention therapy.
Original languageEnglish
PagesFIP-201
Publication statusPublished - 2017
EventFIP World Congress of Pharmacy and Pharmaceutical Sciences 2017 - Seoul, Korea, Republic of
Duration: 10 Sep 201714 Sep 2017

Conference

ConferenceFIP World Congress of Pharmacy and Pharmaceutical Sciences 2017
Abbreviated titleFIP 2017
CountryKorea, Republic of
CitySeoul
Period10/09/201714/09/2017

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