In Situ Gelling Ophthalmic Drug Delivery System: An Overview and Its Applications.

Ravi Sheshala, Yong Yee Kok, Jun Ming Ng, Raghu Raj Singh Thakur, Kamal Dua

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Ophthalmic drug delivery system is very interesting and challenging due to the normal physiologically factor of eyes which reduces the bioavailability of ocular products. The development of a new ophthalmic dosage forms with the existing drugs to improve efficacy and bioavailability including better patients' compliance and convenience has become trend in the most pharmaceutical industries. The present review encompasses various conventional and novel ocular drug delivery systems, methods of preparation, characterization, recent researches carried out. Furthermore, the information on various commercially available in situ gel preparations and the existing patents of in situ drug delivery systems i.e. in situ gel formation of pectin, in situ gel for therapeutic use, medical uses of in situ formed gels and in situ gelling systems as sustained delivery for front of eye also covered in this review.
Original languageEnglish
Pages (from-to)237-248
Number of pages12
JournalRecent Patents on Drug Delivery & Formulation
Issue number3
Early online date23 Jul 2015
Publication statusPublished - Dec 2015


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