In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

Eamon P Rafferty, Alastair R Wylie, Chris T Elliott, Olivier P Chevallier, David J Grieve, Brian D Green

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P
Original languageEnglish
Pages (from-to)615-621
Number of pages7
JournalScientia Pharmaceutica
Volume79
Issue number3
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Pharmaceutical Science

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