In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

Eamon P Rafferty; Alastair R Wylie; Chris T Elliott; Olivier P Chevallier; David J Grieve; Brian D Green

doi:10.3797/scipharm.1104-16

In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

Eamon P Rafferty, Alastair R Wylie, Chris T Elliott, Olivier P Chevallier, David J Grieve, Brian D Green

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P

Original language	English
Pages (from-to)	615-621
Number of pages	7
Journal	Scientia Pharmaceutica
Volume	79
Issue number	3
DOIs	https://doi.org/10.3797/scipharm.1104-16
Publication status	Published - 2011

ASJC Scopus subject areas

Pharmaceutical Science

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title = "In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)",

abstract = "Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P",

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AU - Rafferty, Eamon P

AU - Wylie, Alastair R

AU - Elliott, Chris T

AU - Chevallier, Olivier P

AU - Grieve, David J

AU - Green, Brian D

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AB - Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P

U2 - 10.3797/scipharm.1104-16

DO - 10.3797/scipharm.1104-16

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JO - Scientia Pharmaceutica

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IS - 3

ER -

In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

Abstract

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