In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

Eamon P Rafferty; Alastair R Wylie; Chris T Elliott; Olivier P Chevallier; David J Grieve; Brian D Green

doi:10.3797/scipharm.1104-16

In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

Eamon P Rafferty
, Alastair R Wylie
, Chris T Elliott
, Olivier P Chevallier
, David J Grieve
, Brian D Green

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P

Original language	English
Pages (from-to)	615-621
Number of pages	7
Journal	Scientia Pharmaceutica
Volume	79
Issue number	3
DOIs	https://doi.org/10.3797/scipharm.1104-16
Publication status	Published - 2011

ASJC Scopus subject areas

Pharmaceutical Science

Access to Document

10.3797/scipharm.1104-16

Cite this

@article{33bd2181d9434c3cb2011c08804359d6,

title = "In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)",

abstract = "Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386\%; P",

author = "Rafferty, \{Eamon P\} and Wylie, \{Alastair R\} and Elliott, \{Chris T\} and Chevallier, \{Olivier P\} and Grieve, \{David J\} and Green, \{Brian D\}",

year = "2011",

doi = "10.3797/scipharm.1104-16",

language = "English",

volume = "79",

pages = "615--621",

journal = "Scientia Pharmaceutica",

publisher = "Multidisciplinary Digital Publishing Institute",

number = "3",

}

TY - JOUR

T1 - In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

AU - Rafferty, Eamon P

AU - Wylie, Alastair R

AU - Elliott, Chris T

AU - Chevallier, Olivier P

AU - Grieve, David J

AU - Green, Brian D

PY - 2011

Y1 - 2011

N2 - Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P

AB - Glucagon-like peptide-1 (GLP-1) is an intestinal hormone with well-established glucose-lowering activity. The in vitro and in vivo actions of natural putative secretagogues of GLP-1 were investigated. The acute GLP-1 releasing activity of olive leaf extract (OLE), glutamine (GLN), alpha casein (ACAS), beta casein (BCAS) and chlorogenic acid (CGA) were assessed in STC-1 cells and C57BL/6 mice. All compounds except ACAS significantly increased acute in vitro GLP-1 secretion (66-386%; P

U2 - 10.3797/scipharm.1104-16

DO - 10.3797/scipharm.1104-16

M3 - Article

C2 - 21886907

VL - 79

SP - 615

EP - 621

JO - Scientia Pharmaceutica

JF - Scientia Pharmaceutica

IS - 3

ER -

In Vitro and In Vivo Effects of Natural Putative Secretagogues of Glucagon-Like Peptide-1 (GLP-1)

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this