In vitro and in vivo models of colorectal cancer: Antigenotoxic activity of berries

Emma M. Brown, Cheryl Latimer, Philip Allsopp, Nigel G. Ternan, Geoffery McMullan, Gordon J McDougall, Derek Stewart, Alan Crozier, Ian Rowland, Chris I R Gill*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Citations (Scopus)


The etiology of colorectal cancer (CRC), a common cause of cancer-related mortality globally, has strong associations with diet. There is considerable epidemiological evidence that fruits and vegetables are associated with reduced risk of CRC. This paper reviews the extensive evidence, both from in vitro studies and animal models, that components of berry fruits can modulate biomarkers of DNA damage and that these effects may be potentially chemoprotective, given the likely role that oxidative damage plays in mutation rate and cancer risk. Human intervention trials with berries are generally consistent in indicating a capacity to significantly decrease oxidative damage to DNA, but represent limited evidence for anticarcinogenicity, relying as they do on surrogate risk markers. To understand the effects of berry consumption on colorectal cancer risk, future studies will need to be well controlled, with defined berry extracts, using suitable and clinically relevant end points and considering the importance of the gut microbiota.

Original languageEnglish
Pages (from-to)3852-3866
JournalJournal of Agricultural and Food Chemistry
Issue number18
Early online date21 Jan 2014
Publication statusPublished - 07 May 2014


  • (poly)phenols
  • berries
  • biomarker
  • colon cancer
  • DNA damage
  • fruits and vegetables

ASJC Scopus subject areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)


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