In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)

Julia Balog; Sacheen Kumar; James Alexander; Ottmar Golf; Juzheng Huang; Tom Wiggins; Nima Abbassi-Ghadi; Attila Enyedi; Sandor Kacska; James Kinross; George B. Hanna; Jeremy K. Nicholson; Zoltan Takats

doi:10.1002/anie.201502770

In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)

Julia Balog, Sacheen Kumar, James Alexander, Ottmar Golf, Juzheng Huang, Tom Wiggins, Nima Abbassi-Ghadi, Attila Enyedi, Sandor Kacska, James Kinross, George B. Hanna, Jeremy K. Nicholson, Zoltan Takats^*

^*Corresponding author for this work

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer-related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.

Original language	English
Pages (from-to)	11059-11062
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	54
Issue number	38
DOIs	https://doi.org/10.1002/anie.201502770
Publication status	Published - 01 Jan 2015

Keywords

cancer
endoscopy
in vivo characterization
mass spectrometry
phospholipids

ASJC Scopus subject areas

Catalysis
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Balog, J., Kumar, S., Alexander, J., Golf, O., Huang, J., Wiggins, T., Abbassi-Ghadi, N., Enyedi, A., Kacska, S., Kinross, J., Hanna, G. B., Nicholson, J. K., & Takats, Z. (2015). In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS). Angewandte Chemie - International Edition, 54(38), 11059-11062. https://doi.org/10.1002/anie.201502770

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title = "In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)",

abstract = "Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer-related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.",

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author = "Julia Balog and Sacheen Kumar and James Alexander and Ottmar Golf and Juzheng Huang and Tom Wiggins and Nima Abbassi-Ghadi and Attila Enyedi and Sandor Kacska and James Kinross and Hanna, {George B.} and Nicholson, {Jeremy K.} and Zoltan Takats",

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Balog, J, Kumar, S, Alexander, J, Golf, O, Huang, J, Wiggins, T, Abbassi-Ghadi, N, Enyedi, A, Kacska, S, Kinross, J, Hanna, GB, Nicholson, JK & Takats, Z 2015, 'In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)', Angewandte Chemie - International Edition, vol. 54, no. 38, pp. 11059-11062. https://doi.org/10.1002/anie.201502770

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T1 - In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)

AU - Balog, Julia

AU - Kumar, Sacheen

AU - Alexander, James

AU - Golf, Ottmar

AU - Huang, Juzheng

AU - Wiggins, Tom

AU - Abbassi-Ghadi, Nima

AU - Enyedi, Attila

AU - Kacska, Sandor

AU - Kinross, James

AU - Hanna, George B.

AU - Nicholson, Jeremy K.

AU - Takats, Zoltan

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer-related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.

AB - Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer-related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo.

KW - cancer

KW - endoscopy

KW - in vivo characterization

KW - mass spectrometry

KW - phospholipids

U2 - 10.1002/anie.201502770

DO - 10.1002/anie.201502770

M3 - Article

C2 - 26248566

AN - SCOPUS:84938633337

SN - 1433-7851

VL - 54

SP - 11059

EP - 11062

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 38

ER -

In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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