INCIDENCE AND CLINICAL IMPORTANCE OF PERIOPERATIVE HISTAMINE-RELEASE - RANDOMIZED STUDY OF VOLUME LOADING AND ANTIHISTAMINES AFTER INDUCTION OF ANESTHESIA

W. Lorenz, D. Duda, W. Dick, H. Sitter, A. Doenicke, A. Black, D. Weber, H. Menke, B. Stinner, T. Junginger, M. Rothmund, C. Ohmann, M.J.R. Healy, J. Black, A. Brouwer, H.J. Bruer, W. Dietz, Madeleine Ennis, H. Gajek, D. HeintzbambergH.J. Hennes, B. Kapp, M. Kunneke, M. Marstaller, B. Mcpeek, J. Moss, S. Otto, C. Rehbock, D. Rehn, K.P. Reimund, H.D. Roher, M.S. Rugeles, J. Sattler, A. Scherhag, M. Teschner, R. Zaczyk

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Although histamine release is recognised as a common event during anaesthesia and surgery, few clinicians judge the resultant cardiorespiratory disturbances serious enough to warrant prophylaxis with antihistamines. We have assessed the incidence and importance of histamine release in a randomised 2 x 2 factorial study.
Original languageEnglish
Pages (from-to)933-940
Number of pages8
JournalLancet
Volume343
Publication statusPublished - 1994

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