Incidence of cutaneous melanoma in patients with histologically confirmed dysplastic naevus: a long-term follow up study in a Northern Ireland Healthcare Trust.

Louise McDonald, Corinna Clarke, Joseph Houghton, Finian Bannon, Vikki O'Neill, Olivia Dolan, Collette McCourt

Research output: Contribution to conferenceAbstract

Abstract

Management of dysplastic naevi (DN) is controversial with divided opinion on clinical significance. Recent studies have evaluated recurrence risk and separate site cutaneous melanoma (CM) in patients with DN but a paucity of outcome data remains amongst UK and Irish patients.

We aimed to evaluate long-term outcomes of patients with histologically proven DN in a Northern Ireland Trust providing pathology services to a catchment population of 936,120.

A retrospective review of pathology reported DN was conducted using the Trust Pathology Database between January 1st 2008 - December 31st 2013. Cases were analyzed for demographics, anatomical site, procedure type, histological margins, degree of dysplasia, development of separate site CM and other skin cancers.

248 cases were reported in 243 patients (56% female; median age at diagnosis 44 (range 16-82) with minimum follow-up of 5 years. The majority (93%) had intentional excisional biopsy performed. The back was the commonest site (39%). Histological margins were clear in 93% cases. 15 cases underwent re-excision. Two were upgraded to melanoma (both had involved margins on initial biopsy). Dysplasia severity was documented in 4% of cases. No patients developed CM at the biopsy site. 10 patients had prior CM (n=3), synchronous (n=3) or CM at a separate site (n=4).

Despite the retrospective nature, this is the first study of long-term outcomes of DN in Northern Ireland and supports emerging literature of a low incidence of subsequent CM in patients with histologically confirmed DN and no prior history of CM.
LanguageEnglish
Publication statusPublished - 10 May 2019

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Dysplastic Nevus Syndrome
Northern Ireland
Melanoma
Delivery of Health Care
Skin
Incidence
Pathology
Biopsy
Skin Neoplasms
Demography
Databases
Recurrence

Cite this

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title = "Incidence of cutaneous melanoma in patients with histologically confirmed dysplastic naevus: a long-term follow up study in a Northern Ireland Healthcare Trust.",
abstract = "Management of dysplastic naevi (DN) is controversial with divided opinion on clinical significance. Recent studies have evaluated recurrence risk and separate site cutaneous melanoma (CM) in patients with DN but a paucity of outcome data remains amongst UK and Irish patients. We aimed to evaluate long-term outcomes of patients with histologically proven DN in a Northern Ireland Trust providing pathology services to a catchment population of 936,120. A retrospective review of pathology reported DN was conducted using the Trust Pathology Database between January 1st 2008 - December 31st 2013. Cases were analyzed for demographics, anatomical site, procedure type, histological margins, degree of dysplasia, development of separate site CM and other skin cancers. 248 cases were reported in 243 patients (56{\%} female; median age at diagnosis 44 (range 16-82) with minimum follow-up of 5 years. The majority (93{\%}) had intentional excisional biopsy performed. The back was the commonest site (39{\%}). Histological margins were clear in 93{\%} cases. 15 cases underwent re-excision. Two were upgraded to melanoma (both had involved margins on initial biopsy). Dysplasia severity was documented in 4{\%} of cases. No patients developed CM at the biopsy site. 10 patients had prior CM (n=3), synchronous (n=3) or CM at a separate site (n=4). Despite the retrospective nature, this is the first study of long-term outcomes of DN in Northern Ireland and supports emerging literature of a low incidence of subsequent CM in patients with histologically confirmed DN and no prior history of CM.",
author = "Louise McDonald and Corinna Clarke and Joseph Houghton and Finian Bannon and Vikki O'Neill and Olivia Dolan and Collette McCourt",
year = "2019",
month = "5",
day = "10",
language = "English",

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TY - CONF

T1 - Incidence of cutaneous melanoma in patients with histologically confirmed dysplastic naevus: a long-term follow up study in a Northern Ireland Healthcare Trust.

AU - McDonald, Louise

AU - Clarke, Corinna

AU - Houghton, Joseph

AU - Bannon, Finian

AU - O'Neill, Vikki

AU - Dolan, Olivia

AU - McCourt, Collette

PY - 2019/5/10

Y1 - 2019/5/10

N2 - Management of dysplastic naevi (DN) is controversial with divided opinion on clinical significance. Recent studies have evaluated recurrence risk and separate site cutaneous melanoma (CM) in patients with DN but a paucity of outcome data remains amongst UK and Irish patients. We aimed to evaluate long-term outcomes of patients with histologically proven DN in a Northern Ireland Trust providing pathology services to a catchment population of 936,120. A retrospective review of pathology reported DN was conducted using the Trust Pathology Database between January 1st 2008 - December 31st 2013. Cases were analyzed for demographics, anatomical site, procedure type, histological margins, degree of dysplasia, development of separate site CM and other skin cancers. 248 cases were reported in 243 patients (56% female; median age at diagnosis 44 (range 16-82) with minimum follow-up of 5 years. The majority (93%) had intentional excisional biopsy performed. The back was the commonest site (39%). Histological margins were clear in 93% cases. 15 cases underwent re-excision. Two were upgraded to melanoma (both had involved margins on initial biopsy). Dysplasia severity was documented in 4% of cases. No patients developed CM at the biopsy site. 10 patients had prior CM (n=3), synchronous (n=3) or CM at a separate site (n=4). Despite the retrospective nature, this is the first study of long-term outcomes of DN in Northern Ireland and supports emerging literature of a low incidence of subsequent CM in patients with histologically confirmed DN and no prior history of CM.

AB - Management of dysplastic naevi (DN) is controversial with divided opinion on clinical significance. Recent studies have evaluated recurrence risk and separate site cutaneous melanoma (CM) in patients with DN but a paucity of outcome data remains amongst UK and Irish patients. We aimed to evaluate long-term outcomes of patients with histologically proven DN in a Northern Ireland Trust providing pathology services to a catchment population of 936,120. A retrospective review of pathology reported DN was conducted using the Trust Pathology Database between January 1st 2008 - December 31st 2013. Cases were analyzed for demographics, anatomical site, procedure type, histological margins, degree of dysplasia, development of separate site CM and other skin cancers. 248 cases were reported in 243 patients (56% female; median age at diagnosis 44 (range 16-82) with minimum follow-up of 5 years. The majority (93%) had intentional excisional biopsy performed. The back was the commonest site (39%). Histological margins were clear in 93% cases. 15 cases underwent re-excision. Two were upgraded to melanoma (both had involved margins on initial biopsy). Dysplasia severity was documented in 4% of cases. No patients developed CM at the biopsy site. 10 patients had prior CM (n=3), synchronous (n=3) or CM at a separate site (n=4). Despite the retrospective nature, this is the first study of long-term outcomes of DN in Northern Ireland and supports emerging literature of a low incidence of subsequent CM in patients with histologically confirmed DN and no prior history of CM.

M3 - Abstract

ER -