Increased choroidal thickness in adults with Down’s syndrome

Lajos Csincsik, Rachel Nelson, Madeleine J. Walper, Tunde Peto, Anthony Holland, Imre Lengyel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Introduction: People with Down syndrome (DS) are particularly susceptible to Alzheimer’s disease (AD) due to the triplication of the amyloid precursor protein (APP)gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS.
Methods: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT)was measured and analyzed in relation to cognitive status and cerebral amyloid beta(Aβ) load.
Results: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status.
Discussion: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.
Original languageEnglish
Article numbere12170
Number of pages8
JournalAlzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Issue number1
Publication statusPublished - 17 Mar 2021


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