Increased choroidal thickness in adults with Down’s syndrome

Lajos Csincsik; Rachel  Nelson; Madeleine J.  Walper; Tunde Peto; Anthony  Holland; Imre Lengyel

doi:10.1002/dad2.12170

Increased choroidal thickness in adults with Down’s syndrome

Lajos Csincsik
, Rachel Nelson
, Madeleine J. Walper
, Tunde Peto
, Anthony Holland
, Imre Lengyel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

170 Downloads (Pure)

Abstract

Introduction: People with Down syndrome (DS) are particularly susceptible to Alzheimer’s disease (AD) due to the triplication of the amyloid precursor protein (APP)gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS.
Methods: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT)was measured and analyzed in relation to cognitive status and cerebral amyloid beta(Aβ) load.
Results: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status.
Discussion: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.

Original language	English
Article number	e12170
Number of pages	8
Journal	Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Volume	13
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12170
Publication status	Published - 17 Mar 2021

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Increased choroidal thickness in adults with Down syndrome
Copyright 2021 the authors. This is an open access article published under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
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title = "Increased choroidal thickness in adults with Down{\textquoteright}s syndrome",

abstract = "Introduction: People with Down syndrome (DS) are particularly susceptible to Alzheimer{\textquoteright}s disease (AD) due to the triplication of the amyloid precursor protein (APP)gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS. Methods: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT)was measured and analyzed in relation to cognitive status and cerebral amyloid beta(Aβ) load. Results: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status. Discussion: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.",

author = "Lajos Csincsik and Rachel Nelson and Walper, \{Madeleine J.\} and Tunde Peto and Anthony Holland and Imre Lengyel",

year = "2021",

month = mar,

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doi = "10.1002/dad2.12170",

language = "English",

volume = "13",

journal = "Alzheimer's \& Dementia: Diagnosis, Assessment \& Disease Monitoring",

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T1 - Increased choroidal thickness in adults with Down’s syndrome

AU - Csincsik, Lajos

AU - Nelson, Rachel

AU - Walper, Madeleine J.

AU - Peto, Tunde

AU - Holland, Anthony

AU - Lengyel, Imre

PY - 2021/3/17

Y1 - 2021/3/17

N2 - Introduction: People with Down syndrome (DS) are particularly susceptible to Alzheimer’s disease (AD) due to the triplication of the amyloid precursor protein (APP)gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS. Methods: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT)was measured and analyzed in relation to cognitive status and cerebral amyloid beta(Aβ) load. Results: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status. Discussion: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.

AB - Introduction: People with Down syndrome (DS) are particularly susceptible to Alzheimer’s disease (AD) due to the triplication of the amyloid precursor protein (APP)gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS. Methods: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl) were imaged with optical coherence tomography. Choroidal thickness (ChT)was measured and analyzed in relation to cognitive status and cerebral amyloid beta(Aβ) load. Results: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlated with cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status. Discussion: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation.

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DO - 10.1002/dad2.12170

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JF - Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

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Increased choroidal thickness in adults with Down’s syndrome

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