Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance

Tracy Robson, M.E. Price, M.L. Moore, M.C. Joiner, V.J. McKelvey-Martin, S.R. McKeown, David Hirst

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Purpose: To determine whether repression of a recently isolated, X-ray-responsive gene, DIR1, using antisense oligonucleotides could affect clonogenic cell survival and repair of DNA strand breaks and have a possible role in the mechanism underlying the phenomenon of 'induced radioresistance' (IRR).
Original languageEnglish
Pages (from-to)617-623
Number of pages7
JournalInternational journal of radiation biology
Volume76
Issue number5
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Nuclear Energy and Engineering
  • Radiation

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    Robson, T., Price, M. E., Moore, M. L., Joiner, M. C., McKelvey-Martin, V. J., McKeown, S. R., & Hirst, D. (2000). Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. International journal of radiation biology, 76(5), 617-623.