Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes

A J Jenkins; S X Zhang; K G Rowley; C S Karschimkus; C L Nelson; J S Chung; D N O'Neal; A S Januszewski; K D Croft; T A Mori; G Dragicevic; C A Harper; J D Best; T J Lyons; J-X Ma

doi:10.1111/j.1464-5491.2007.02281.x

Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes

A J Jenkins, S X Zhang, K G Rowley, C S Karschimkus, C L Nelson, J S Chung, D N O'Neal, A S Januszewski, K D Croft, T A Mori, G Dragicevic, C A Harper, J D Best, T J Lyons, J-X Ma

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

70 Citations (Scopus)

Abstract

To determine in Type 1 diabetes patients if levels of pigment epithelium-derived factor (PEDF), an anti-angiogenic, anti-inflammatory and antioxidant factor, are increased in individuals with complications and positively related to vascular and renal dysfunction, body mass index, glycated haemoglobin, lipids, inflammation and oxidative stress.

Original language	English
Pages (from-to)	1345-51
Number of pages	7
Journal	Diabetic Medicine
Volume	24
Issue number	12
DOIs	https://doi.org/10.1111/j.1464-5491.2007.02281.x
Publication status	Published - Dec 2007

Keywords

Adult
Biological Markers
Body Mass Index
C-Reactive Protein
Cross-Sectional Studies
Diabetes Mellitus, Type 1
Diabetic Nephropathies
Diabetic Retinopathy
Enzyme-Linked Immunosorbent Assay
Eye Proteins
Female
Hemoglobin A, Glycosylated
Humans
Male
Middle Aged
Nerve Growth Factors
Oxidative Stress
Protease Inhibitors
Serpins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/j.1464-5491.2007.02281.x

Cite this

Jenkins, A. J., Zhang, S. X., Rowley, K. G., Karschimkus, C. S., Nelson, C. L., Chung, J. S., O'Neal, D. N., Januszewski, A. S., Croft, K. D., Mori, T. A., Dragicevic, G., Harper, C. A., Best, J. D., Lyons, T. J., & Ma, J-X. (2007). Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes. Diabetic Medicine, 24(12), 1345-51. https://doi.org/10.1111/j.1464-5491.2007.02281.x

@article{bdaf51ed1e7241e29c1501d0850eb79d,

title = "Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes",

abstract = "To determine in Type 1 diabetes patients if levels of pigment epithelium-derived factor (PEDF), an anti-angiogenic, anti-inflammatory and antioxidant factor, are increased in individuals with complications and positively related to vascular and renal dysfunction, body mass index, glycated haemoglobin, lipids, inflammation and oxidative stress.",

keywords = "Adult, Biological Markers, Body Mass Index, C-Reactive Protein, Cross-Sectional Studies, Diabetes Mellitus, Type 1, Diabetic Nephropathies, Diabetic Retinopathy, Enzyme-Linked Immunosorbent Assay, Eye Proteins, Female, Hemoglobin A, Glycosylated, Humans, Male, Middle Aged, Nerve Growth Factors, Oxidative Stress, Protease Inhibitors, Serpins",

author = "Jenkins, {A J} and Zhang, {S X} and Rowley, {K G} and Karschimkus, {C S} and Nelson, {C L} and Chung, {J S} and O'Neal, {D N} and Januszewski, {A S} and Croft, {K D} and Mori, {T A} and G Dragicevic and Harper, {C A} and Best, {J D} and Lyons, {T J} and J-X Ma",

year = "2007",

month = dec,

doi = "10.1111/j.1464-5491.2007.02281.x",

language = "English",

volume = "24",

pages = "1345--51",

journal = "Diabetic Medicine",

issn = "0742-3071",

publisher = "Wiley-Blackwell",

number = "12",

}

Jenkins, AJ, Zhang, SX, Rowley, KG, Karschimkus, CS, Nelson, CL, Chung, JS, O'Neal, DN, Januszewski, AS, Croft, KD, Mori, TA, Dragicevic, G, Harper, CA, Best, JD, Lyons, TJ & Ma, J-X 2007, 'Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes', Diabetic Medicine, vol. 24, no. 12, pp. 1345-51. https://doi.org/10.1111/j.1464-5491.2007.02281.x

TY - JOUR

T1 - Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes

AU - Jenkins, A J

AU - Zhang, S X

AU - Rowley, K G

AU - Karschimkus, C S

AU - Nelson, C L

AU - Chung, J S

AU - O'Neal, D N

AU - Januszewski, A S

AU - Croft, K D

AU - Mori, T A

AU - Dragicevic, G

AU - Harper, C A

AU - Best, J D

AU - Lyons, T J

AU - Ma, J-X

PY - 2007/12

Y1 - 2007/12

N2 - To determine in Type 1 diabetes patients if levels of pigment epithelium-derived factor (PEDF), an anti-angiogenic, anti-inflammatory and antioxidant factor, are increased in individuals with complications and positively related to vascular and renal dysfunction, body mass index, glycated haemoglobin, lipids, inflammation and oxidative stress.

AB - To determine in Type 1 diabetes patients if levels of pigment epithelium-derived factor (PEDF), an anti-angiogenic, anti-inflammatory and antioxidant factor, are increased in individuals with complications and positively related to vascular and renal dysfunction, body mass index, glycated haemoglobin, lipids, inflammation and oxidative stress.

KW - Adult

KW - Biological Markers

KW - Body Mass Index

KW - C-Reactive Protein

KW - Cross-Sectional Studies

KW - Diabetes Mellitus, Type 1

KW - Diabetic Nephropathies

KW - Diabetic Retinopathy

KW - Enzyme-Linked Immunosorbent Assay

KW - Eye Proteins

KW - Female

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Male

KW - Middle Aged

KW - Nerve Growth Factors

KW - Oxidative Stress

KW - Protease Inhibitors

KW - Serpins

U2 - 10.1111/j.1464-5491.2007.02281.x

DO - 10.1111/j.1464-5491.2007.02281.x

M3 - Article

C2 - 17971181

VL - 24

SP - 1345

EP - 1351

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 12

ER -

Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this