Increased serum pigment epithelium-derived factor is associated with microvascular complications, vascular stiffness and inflammation in Type 1 diabetes

A J Jenkins, S X Zhang, K G Rowley, C S Karschimkus, C L Nelson, J S Chung, D N O'Neal, A S Januszewski, K D Croft, T A Mori, G Dragicevic, C A Harper, J D Best, T J Lyons, J-X Ma

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

To determine in Type 1 diabetes patients if levels of pigment epithelium-derived factor (PEDF), an anti-angiogenic, anti-inflammatory and antioxidant factor, are increased in individuals with complications and positively related to vascular and renal dysfunction, body mass index, glycated haemoglobin, lipids, inflammation and oxidative stress.
Original languageEnglish
Pages (from-to)1345-51
Number of pages7
JournalDiabetic Medicine
Volume24
Issue number12
DOIs
Publication statusPublished - Dec 2007

Keywords

  • Adult
  • Biological Markers
  • Body Mass Index
  • C-Reactive Protein
  • Cross-Sectional Studies
  • Diabetes Mellitus, Type 1
  • Diabetic Nephropathies
  • Diabetic Retinopathy
  • Enzyme-Linked Immunosorbent Assay
  • Eye Proteins
  • Female
  • Hemoglobin A, Glycosylated
  • Humans
  • Male
  • Middle Aged
  • Nerve Growth Factors
  • Oxidative Stress
  • Protease Inhibitors
  • Serpins

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