Increasing incidence of Barrett's oesophagus: a population-based study

Helen G. Coleman*, Shivaram Bhat, Liam J. Murray, Damian McManus, Anna T. Gavin, Brian T. Johnston

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Citations (Scopus)
188 Downloads (Pure)

Abstract

Oesophageal adenocarcinoma, a highly fatal cancer, has risen in incidence in Western societies, but it is unclear whether this is due to increasing incidence of its precursor condition, Barrett’s oesophagus (BO) or whether the proportion of BO patients undergoing malignant progression has increased in the face of unchanged BO incidence. Data from population-based studies of BO incidence is limited, with equivocal results to date difficult to distinguish from changes in endoscopic practices. The aim of this study was to assess population trends in Barrett’s oesophagus (BO) diagnoses in relation to endoscopy and biopsy rates over a 13 year period. The Northern Ireland Barrett’s oesophagus Register (NIBR) is a population-based register of all 9,329 adults diagnosed with columnar epithelium of the oesophagus in Northern Ireland between 1993 and 2005, of whom 58.3% were male. European age-standardised annual BO incidence rates were calculated per 100,000 of the population, per 100 endoscopies and per 100 endoscopies including an oesophageal biopsy. Average annual BO incidence rates rose by 159% during the study period, increasing from 23.9/100,000 during1993–1997 to 62.0/100,000 during 2002–2005. This elevation far exceeded corresponding increases in rates of endoscopies and oesophageal biopsies being conducted. BO incidence increased most markedly in individuals aged <60 years, and most notably amongst males aged <40 years. This study points towards a true increase in the incidence of BO which would appear to be most marked in young males. These findings have significant implications for future rates ofoesophageal adenocarcinoma and surveillance programmes.
Original languageEnglish
Pages (from-to)739-745
JournalEuropean Journal of Epidemiology
Volume26
Issue number9
Early online date14 Jun 2011
DOIs
Publication statusPublished - 01 Sept 2011

ASJC Scopus subject areas

  • Epidemiology

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