Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

Heather Anderson, A. W. Stitt, T. A. Gardiner, S. J. Lloyd, D. B. Archer

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


The diabetic dog represents an excellent model for use in many aspects of diabetic research. The present paper describes, in detail, a reproducible experimental protocol for the successful induction of chemical diabetes in beagles using a combination of the 2 pancreatic beta-cell cytoxic agents alloxan and streptozotocin.
Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalLaboratory animals
Issue number3
Publication statusPublished - 01 Jul 1993

Bibliographical note

LR: 20031114; JID: 0112725; 0 (Blood Glucose); 0 (Hartman's solution); 18883-66-4 (Streptozocin); 50-71-5 (Alloxan); 50-99-7 (Glucose); 89-83-8 (Thymol); ppublish


  • Alloxan
  • Animals
  • Blood Glucose/drug effects/metabolism
  • Diabetes Mellitus, Experimental/blood/chemically induced
  • Disease Models, Animal
  • Dogs
  • Glucose/administration & dosage
  • Reproducibility of Results
  • Streptozocin
  • Thymol/administration & dosage


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