Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

Heather Anderson; A. W. Stitt; T. A. Gardiner; S. J. Lloyd; D. B. Archer

Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

Heather Anderson
, A. W. Stitt
, T. A. Gardiner
, S. J. Lloyd
, D. B. Archer

Research output: Contribution to journal › Article › peer-review

Abstract

The diabetic dog represents an excellent model for use in many aspects of diabetic research. The present paper describes, in detail, a reproducible experimental protocol for the successful induction of chemical diabetes in beagles using a combination of the 2 pancreatic beta-cell cytoxic agents alloxan and streptozotocin.

Original language	English
Pages (from-to)	281-285
Number of pages	5
Journal	Laboratory animals
Volume	27
Issue number	3
Publication status	Published - 01 Jul 1993

Bibliographical note

LR: 20031114; JID: 0112725; 0 (Blood Glucose); 0 (Hartman's solution); 18883-66-4 (Streptozocin); 50-71-5 (Alloxan); 50-99-7 (Glucose); 89-83-8 (Thymol); ppublish

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alloxan
Animals
Blood Glucose/drug effects/metabolism
Diabetes Mellitus, Experimental/blood/chemically induced
Disease Models, Animal
Dogs
Glucose/administration & dosage
Reproducibility of Results
Streptozocin
Thymol/administration & dosage

Cite this

@article{7365854f66bc41fa8d467995dda1e488,

title = "Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique",

abstract = "The diabetic dog represents an excellent model for use in many aspects of diabetic research. The present paper describes, in detail, a reproducible experimental protocol for the successful induction of chemical diabetes in beagles using a combination of the 2 pancreatic beta-cell cytoxic agents alloxan and streptozotocin.",

keywords = "Alloxan, Animals, Blood Glucose/drug effects/metabolism, Diabetes Mellitus, Experimental/blood/chemically induced, Disease Models, Animal, Dogs, Glucose/administration \& dosage, Reproducibility of Results, Streptozocin, Thymol/administration \& dosage",

author = "Heather Anderson and Stitt, \{A. W.\} and Gardiner, \{T. A.\} and Lloyd, \{S. J.\} and Archer, \{D. B.\}",

note = "LR: 20031114; JID: 0112725; 0 (Blood Glucose); 0 (Hartman's solution); 18883-66-4 (Streptozocin); 50-71-5 (Alloxan); 50-99-7 (Glucose); 89-83-8 (Thymol); ppublish",

year = "1993",

month = jul,

day = "1",

language = "English",

volume = "27",

pages = "281--285",

journal = "Laboratory animals",

issn = "1758-1117",

publisher = "Sage Publications Ltd",

number = "3",

}

TY - JOUR

T1 - Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

AU - Anderson, Heather

AU - Stitt, A. W.

AU - Gardiner, T. A.

AU - Lloyd, S. J.

AU - Archer, D. B.

N1 - LR: 20031114; JID: 0112725; 0 (Blood Glucose); 0 (Hartman's solution); 18883-66-4 (Streptozocin); 50-71-5 (Alloxan); 50-99-7 (Glucose); 89-83-8 (Thymol); ppublish

PY - 1993/7/1

Y1 - 1993/7/1

N2 - The diabetic dog represents an excellent model for use in many aspects of diabetic research. The present paper describes, in detail, a reproducible experimental protocol for the successful induction of chemical diabetes in beagles using a combination of the 2 pancreatic beta-cell cytoxic agents alloxan and streptozotocin.

AB - The diabetic dog represents an excellent model for use in many aspects of diabetic research. The present paper describes, in detail, a reproducible experimental protocol for the successful induction of chemical diabetes in beagles using a combination of the 2 pancreatic beta-cell cytoxic agents alloxan and streptozotocin.

KW - Alloxan

KW - Animals

KW - Blood Glucose/drug effects/metabolism

KW - Diabetes Mellitus, Experimental/blood/chemically induced

KW - Disease Models, Animal

KW - Dogs

KW - Glucose/administration & dosage

KW - Reproducibility of Results

KW - Streptozocin

KW - Thymol/administration & dosage

M3 - Article

C2 - 8366676

SN - 1758-1117

VL - 27

SP - 281

EP - 285

JO - Laboratory animals

JF - Laboratory animals

IS - 3

ER -

Induction of alloxan/streptozotocin diabetes in dogs: a revised experimental technique

Abstract

Bibliographical note

UN SDGs

Keywords

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Cite this