Induction of hypertrophic responsiveness of cardiomyocytes to neuropeptide Y in response to pressure overload.

David Bell, A.R. Allen, Elizabeth Kelso, A. Balasubramaniam, Barbara McDermott

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

To determine whether neuropeptide Y (NPY)-related mechanisms become activated with progression of cardiac hypertrophy in vivo, protein mass and de novo protein synthesis (incorporation of [(14)C]Phe, 0.1 muCi ml(-1)) were assessed in cardiomyocytes, obtained from spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (8, 12, 16, 20, and 24 weeks of age), and cultured for 24 h. NPY (10(-8) M) increased protein mass of cardiomyocytes from 16-week-old SHRs by 9.2 +/- 2.1% (n = 8, P
Original languageEnglish
Pages (from-to)581-591
Number of pages11
JournalJournal of Pharmacology and Experimental Therapeutics
Volume303 (2)
Issue number2
DOIs
Publication statusPublished - 01 Nov 2002

ASJC Scopus subject areas

  • Pharmacology

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