Abstract
To determine whether neuropeptide Y (NPY)-related mechanisms become activated with progression of cardiac hypertrophy in vivo, protein mass and de novo protein synthesis (incorporation of [(14)C]Phe, 0.1 muCi ml(-1)) were assessed in cardiomyocytes, obtained from spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (8, 12, 16, 20, and 24 weeks of age), and cultured for 24 h. NPY (10(-8) M) increased protein mass of cardiomyocytes from 16-week-old SHRs by 9.2 +/- 2.1% (n = 8, P
| Original language | English |
|---|---|
| Pages (from-to) | 581-591 |
| Number of pages | 11 |
| Journal | Journal of Pharmacology and Experimental Therapeutics |
| Volume | 303 (2) |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 01 Nov 2002 |
ASJC Scopus subject areas
- Pharmacology
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Bell, D., Allen, A. R., Kelso, E., Balasubramaniam, A., & McDermott, B. (2002). Induction of hypertrophic responsiveness of cardiomyocytes to neuropeptide Y in response to pressure overload. Journal of Pharmacology and Experimental Therapeutics, 303 (2)(2), 581-591. https://doi.org/10.1124/jpet.102.038448