TY - JOUR
T1 - Induction of hypertrophic responsiveness of cardiomyocytes to neuropeptide Y in response to pressure overload.
AU - Bell, David
AU - Allen, A.R.
AU - Kelso, Elizabeth
AU - Balasubramaniam, A.
AU - McDermott, Barbara
PY - 2002/11/1
Y1 - 2002/11/1
N2 - To determine whether neuropeptide Y (NPY)-related mechanisms become activated with progression of cardiac hypertrophy in vivo, protein mass and de novo protein synthesis (incorporation of [(14)C]Phe, 0.1 muCi ml(-1)) were assessed in cardiomyocytes, obtained from spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (8, 12, 16, 20, and 24 weeks of age), and cultured for 24 h. NPY (10(-8) M) increased protein mass of cardiomyocytes from 16-week-old SHRs by 9.2 +/- 2.1% (n = 8, P
AB - To determine whether neuropeptide Y (NPY)-related mechanisms become activated with progression of cardiac hypertrophy in vivo, protein mass and de novo protein synthesis (incorporation of [(14)C]Phe, 0.1 muCi ml(-1)) were assessed in cardiomyocytes, obtained from spontaneously hypertensive rats (SHRs) and normotensive Wistar Kyoto rats (8, 12, 16, 20, and 24 weeks of age), and cultured for 24 h. NPY (10(-8) M) increased protein mass of cardiomyocytes from 16-week-old SHRs by 9.2 +/- 2.1% (n = 8, P
UR - http://www.scopus.com/inward/record.url?scp=0036827571&partnerID=8YFLogxK
U2 - 10.1124/jpet.102.038448
DO - 10.1124/jpet.102.038448
M3 - Article
VL - 303 (2)
SP - 581
EP - 591
JO - Journal of Pharmacology and Experimental Therapeutics
JF - Journal of Pharmacology and Experimental Therapeutics
SN - 0022-3565
IS - 2
ER -