Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease

Alessandra Bragonzi, Hamed Horati, Lauren Kerrigan, Nicola Ivan Lorè, Bob J Scholte, Sinead Weldon

Research output: Contribution to journalSpecial issue

5 Citations (Scopus)

Abstract

Cystic Fibrosis (CF) lung disease is associated with dysregulation of host defence systems, which ultimately disrupts the balance between inflammation and resolution and leaves the host susceptible to repeated infection. However, the mechanisms underlying these defects are complex and continue to garner significant interest among the CF research community. This review explores emerging data on novel aspects of innate host defence with promising biomarker and therapeutic potential for CF lung disease. Improved understanding of inflammation and host defence against pathogens in patients and animal models during the progression of CF lung disease is pivotal for the discovery of new therapeutics that can limit and/or prevent damage from birth.
Original languageEnglish
Pages (from-to)S40- S45
JournalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume17
Issue number2 (Supplement)
DOIs
Publication statusPublished - Oct 2017

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Host-Pathogen Interactions
Cystic Fibrosis
Lung Diseases
Inflammation
Animal Models
Biomarkers
Parturition
Therapeutics
Infection
Research

Cite this

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title = "Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease",
abstract = "Cystic Fibrosis (CF) lung disease is associated with dysregulation of host defence systems, which ultimately disrupts the balance between inflammation and resolution and leaves the host susceptible to repeated infection. However, the mechanisms underlying these defects are complex and continue to garner significant interest among the CF research community. This review explores emerging data on novel aspects of innate host defence with promising biomarker and therapeutic potential for CF lung disease. Improved understanding of inflammation and host defence against pathogens in patients and animal models during the progression of CF lung disease is pivotal for the discovery of new therapeutics that can limit and/or prevent damage from birth.",
author = "Alessandra Bragonzi and Hamed Horati and Lauren Kerrigan and Lorè, {Nicola Ivan} and Scholte, {Bob J} and Sinead Weldon",
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language = "English",
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Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease. / Bragonzi, Alessandra; Horati, Hamed ; Kerrigan, Lauren; Lorè, Nicola Ivan; Scholte, Bob J ; Weldon, Sinead.

In: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, Vol. 17, No. 2 (Supplement), 10.2017, p. S40- S45.

Research output: Contribution to journalSpecial issue

TY - JOUR

T1 - Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease

AU - Bragonzi, Alessandra

AU - Horati, Hamed

AU - Kerrigan, Lauren

AU - Lorè, Nicola Ivan

AU - Scholte, Bob J

AU - Weldon, Sinead

PY - 2017/10

Y1 - 2017/10

N2 - Cystic Fibrosis (CF) lung disease is associated with dysregulation of host defence systems, which ultimately disrupts the balance between inflammation and resolution and leaves the host susceptible to repeated infection. However, the mechanisms underlying these defects are complex and continue to garner significant interest among the CF research community. This review explores emerging data on novel aspects of innate host defence with promising biomarker and therapeutic potential for CF lung disease. Improved understanding of inflammation and host defence against pathogens in patients and animal models during the progression of CF lung disease is pivotal for the discovery of new therapeutics that can limit and/or prevent damage from birth.

AB - Cystic Fibrosis (CF) lung disease is associated with dysregulation of host defence systems, which ultimately disrupts the balance between inflammation and resolution and leaves the host susceptible to repeated infection. However, the mechanisms underlying these defects are complex and continue to garner significant interest among the CF research community. This review explores emerging data on novel aspects of innate host defence with promising biomarker and therapeutic potential for CF lung disease. Improved understanding of inflammation and host defence against pathogens in patients and animal models during the progression of CF lung disease is pivotal for the discovery of new therapeutics that can limit and/or prevent damage from birth.

U2 - 10.1016/j.jcf.2017.10.004

DO - 10.1016/j.jcf.2017.10.004

M3 - Special issue

VL - 17

SP - S40- S45

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

SN - 1569-1993

IS - 2 (Supplement)

ER -