Inflammatory and immunological biomarkers are not related to survival in adults with Cystic Fibrosis

K. L. Moffitt, S. Lorraine Martin, A. M. Jones, A. K. Webb, C. Cardwell, M. M. Tunney, J. S. Elborn

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Background
Chronic Pseudomonas aeruginosa pulmonary infection is associated with a decline in lung function and reduced survival in people with Cystic Fibrosis (CF). Damaging inflammatory and immunological mediators released in the lungs can be used as markers of chronic infection, inflammation and lung tissue damage.

Methods
Clinical samples were collected from CF patients and healthy controls. Serum IgG and IgA anti-Pseudomonas antibodies, sputum IL-8 and TNFα, plasma IL-6 and urine TNFr1 were measured by ELISA. Sputum neutrophil elastase (NE), cathepsin S and cathepsin B were measured by spectrophotometric and fluorogenic assays. The relationship between IgG and IgA, inflammatory mediators and long-term survival was determined.

Results
IgG and IL-6 positively correlated with mortality. However, multivariate analysis demonstrated that after adjusting for FEV1, IgG was not independently related to mortality. A relationship was observed between IgG and IL-6, TNFα, TNFr1 and between IgA and IL8, cathepsin S and cathepsin B.

Conclusions
These data indicate that biomarkers of inflammation are not independent predictors of survival in people with CF.
Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalJournal of Cystic Fibrosis
Volume13
Issue number1
Early online date13 Jul 2013
DOIs
Publication statusPublished - Jan 2014

Bibliographical note

© 2013.

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Inflammatory and immunological biomarkers are not related to survival in adults with Cystic Fibrosis'. Together they form a unique fingerprint.

Cite this