Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study

Paula Jakszyn, Valerie Cayssials, Genevieve Buckland, Aurora Perez-Cornago, Elisabete Weiderpass, Heiner Boeing, Manuela M Bergmann, Alexandra Vulcan, Bodil Ohlsson, Giovanna Masala, Amanda J Cross, Elio Riboli, Fulvio Ricceri, Christina C Dahm, Dorthe Nyvang, Verena A Katzke, Tilman Kühn, Cecilie Kyrø, Anne Tjønneland, Heather A WardKonstantinos K Tsilidis, Guri Skeie, Sabina Sieri, Maria-Jose Sanchez, Jose M Huerta, Pilar Amiano, Cristina Lasheras, Eva Ardanaz, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Franck Carbonnel, Salvatore Panico, Eleni Peppa, Antonia Trichopoulou, Anna Karakatsani, Rosario Tumino, Roel Vermeulen, Mazda Jenab, Marc Gunter, Antonio Agudo

Research output: Contribution to journalArticle

Abstract

Proinflammatory diets are associated with risk of developing colorectal cancer (CRC), however, inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute toward a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumors). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More proinflammatory diets were related to a higher CRC risk, particularly for colon cancer; hazard ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval [CI] 1.04-1.27) for CRC, 1.24 (95% CI 1.09-1.41) for colon cancer and 0.99 (95% CI 0.83-1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS was 1.62 (95% CI 1.31-2.01) for colon cancer overall and 2.11 (95% CI 1.50-2.97) for colon cancer in men. Our study shows that more proinflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men.

Original languageEnglish
JournalInternational Journal of Cancer
Early online date16 Jan 2020
DOIs
Publication statusEarly online date - 16 Jan 2020

Bibliographical note

© 2020 UICC.

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    Jakszyn, P., Cayssials, V., Buckland, G., Perez-Cornago, A., Weiderpass, E., Boeing, H., Bergmann, M. M., Vulcan, A., Ohlsson, B., Masala, G., Cross, A. J., Riboli, E., Ricceri, F., Dahm, C. C., Nyvang, D., Katzke, V. A., Kühn, T., Kyrø, C., Tjønneland, A., ... Agudo, A. (2020). Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study. International Journal of Cancer. https://doi.org/10.1002/ijc.32870