Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches

Desmond Morrow, Paul McCarron, David Woolfson, P. Juzenas, A. Juzeniene, V. Iani, J. Moan, Ryan Donnelly

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives The inclusion 01 chemical penetration enhancers in a novel patch-based system for the delivery of 5-aminolevulinic acid (ALA) was examined in vitro and in vivo. Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions. such as nodular basal cell carcinomas.
Original languageEnglish
Pages (from-to)685-695
Number of pages11
JournalJournal of Pharmacy and Pharmacology
Volume62
Issue number6
DOIs
Publication statusPublished - Jun 2010

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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