Objectives The inclusion 01 chemical penetration enhancers in a novel patch-based system for the delivery of 5-aminolevulinic acid (ALA) was examined in vitro and in vivo. Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions. such as nodular basal cell carcinomas.
ASJC Scopus subject areas
- Pharmaceutical Science
Morrow, D., McCarron, P., Woolfson, D., Juzenas, P., Juzeniene, A., Iani, V., Moan, J., & Donnelly, R. (2010). Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches. Journal of Pharmacy and Pharmacology, 62(6), 685-695. https://doi.org/10.1211/jpp/62.06.0004