Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches

Desmond Morrow; Paul McCarron; David Woolfson; P. Juzenas; A. Juzeniene; V. Iani; J. Moan; Ryan Donnelly

doi:10.1211/jpp/62.06.0004

Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches

Desmond Morrow, Paul McCarron, David Woolfson, P. Juzenas, A. Juzeniene, V. Iani, J. Moan, Ryan Donnelly

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Objectives The inclusion 01 chemical penetration enhancers in a novel patch-based system for the delivery of 5-aminolevulinic acid (ALA) was examined in vitro and in vivo. Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions. such as nodular basal cell carcinomas.

Original language	English
Pages (from-to)	685-695
Number of pages	11
Journal	Journal of Pharmacy and Pharmacology
Volume	62
Issue number	6
DOIs	https://doi.org/10.1211/jpp/62.06.0004
Publication status	Published - Jun 2010

ASJC Scopus subject areas

Pharmaceutical Science
Pharmacology

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10.1211/jpp/62.06.0004

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abstract = "Objectives The inclusion 01 chemical penetration enhancers in a novel patch-based system for the delivery of 5-aminolevulinic acid (ALA) was examined in vitro and in vivo. Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions. such as nodular basal cell carcinomas.",

author = "Desmond Morrow and Paul McCarron and David Woolfson and P. Juzenas and A. Juzeniene and V. Iani and J. Moan and Ryan Donnelly",

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AU - Morrow, Desmond

AU - McCarron, Paul

AU - Woolfson, David

AU - Juzenas, P.

AU - Juzeniene, A.

AU - Iani, V.

AU - Moan, J.

AU - Donnelly, Ryan

PY - 2010/6

Y1 - 2010/6

N2 - Objectives The inclusion 01 chemical penetration enhancers in a novel patch-based system for the delivery of 5-aminolevulinic acid (ALA) was examined in vitro and in vivo. Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions. such as nodular basal cell carcinomas.

AB - Objectives The inclusion 01 chemical penetration enhancers in a novel patch-based system for the delivery of 5-aminolevulinic acid (ALA) was examined in vitro and in vivo. Poor penetration of ALA has been implicated as the primary factor for low response rates achieved with topical ALA-based photodynamic therapy of thicker neoplastic lesions. such as nodular basal cell carcinomas.

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DO - 10.1211/jpp/62.06.0004

M3 - Article

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SP - 685

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JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

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ER -

Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches

Abstract

ASJC Scopus subject areas

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