INFLUENCE OF ULTRASOUND ON THE PERCUTANEOUS-ABSORPTION OF NICOTINATE ESTERS

H.A.E. Benson, James McElnay, R. Harland, J. Hadgraft

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)

Abstract

The influence of ultrasound on the percutaneous absorption of three nicotinate esters was investigated in 10 healthy volunteers in a double-blind placebo controlled crossover clinical trial. Using a specially designed experimental protocol, the effect of continuous output ultrasound (at frequency 3.0 MHz and intensity 1.0 W/cm2 for 5 min) on the percutaneous absorption of methyl, ethyl, and hexyl nicotinates, from gel bases, was investigated. A placebo control, involving massage with each of the gels, without ultrasound for 5 min, was also incorporated. The pharmacodynamic parameter of vasodilation caused by the nicotinates was used to monitor the percutaneous absorption of the drugs. Laser Doppler velocimetry, a noninvasive optical technique, was used to measure vasodilation of the cutaneous vessels within the treatment site. Ultrasound treatment led to enhanced vasodilator response to the nicotinates, therefore indicating an enhancement of their percutaneous absorption. These agents may prove to be useful compounds in examination of the mechanism of action of phonophoresis.
Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalPharmaceutical Research
Volume8
Publication statusPublished - 1991

Fingerprint Dive into the research topics of 'INFLUENCE OF ULTRASOUND ON THE PERCUTANEOUS-ABSORPTION OF NICOTINATE ESTERS'. Together they form a unique fingerprint.

Cite this