Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards

J. Summers; G. Diesel; L. Asher; P.D. McGreevy; Lisa Collins

doi:10.1016/j.tvjl.2009.11.002

Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards

J. Summers, G. Diesel, L. Asher, P.D. McGreevy, Lisa Collins

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Recent debate concerning health problems in pedigree animals has highlighted gaps in current knowledge of the prevalence, severity and welfare implications of deleterious inherited traits within the pedigree dog population. In this second part of a two-part review, inherited disorders in the top 50 UK Kennel Club registered breeds were researched using systematic searches of existing databases. A set of inclusion and exclusion criteria, including an evidence strength scale (SEHB), were applied to search results. A total of 312 non-conformation linked inherited disorders was identified, with German shepherd dogs and Golden retrievers associated with the greatest number of disorders. The most commonly reported mode of inheritance was autosomal recessive (71%; 57 breed-disorder combinations), and the most common primarily affected body system was the nervous sensory system. To provide a true assessment of the scale of inherited disorders in the pedigree dogs studied more effort is required to collect accurate prevalence data.

Original language	English
Pages (from-to)	39-45
Number of pages	7
Journal	The Veterinary Journal
Volume	183
Issue number	1
DOIs	https://doi.org/10.1016/j.tvjl.2009.11.002
Publication status	Published - Jan 2010

ASJC Scopus subject areas

Animal Science and Zoology
veterinary(all)

Access to Document

10.1016/j.tvjl.2009.11.002

Cite this

@article{1ff6f0239750478d8758d35a69070e41,

title = "Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards",

abstract = "Recent debate concerning health problems in pedigree animals has highlighted gaps in current knowledge of the prevalence, severity and welfare implications of deleterious inherited traits within the pedigree dog population. In this second part of a two-part review, inherited disorders in the top 50 UK Kennel Club registered breeds were researched using systematic searches of existing databases. A set of inclusion and exclusion criteria, including an evidence strength scale (SEHB), were applied to search results. A total of 312 non-conformation linked inherited disorders was identified, with German shepherd dogs and Golden retrievers associated with the greatest number of disorders. The most commonly reported mode of inheritance was autosomal recessive (71%; 57 breed-disorder combinations), and the most common primarily affected body system was the nervous sensory system. To provide a true assessment of the scale of inherited disorders in the pedigree dogs studied more effort is required to collect accurate prevalence data. ",

author = "J. Summers and G. Diesel and L. Asher and P.D. McGreevy and Lisa Collins",

year = "2010",

month = jan,

doi = "10.1016/j.tvjl.2009.11.002",

language = "English",

volume = "183",

pages = "39--45",

journal = "The Veterinary Journal",

issn = "1090-0233",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards

AU - Summers, J.

AU - Diesel, G.

AU - Asher, L.

AU - McGreevy, P.D.

AU - Collins, Lisa

PY - 2010/1

Y1 - 2010/1

N2 - Recent debate concerning health problems in pedigree animals has highlighted gaps in current knowledge of the prevalence, severity and welfare implications of deleterious inherited traits within the pedigree dog population. In this second part of a two-part review, inherited disorders in the top 50 UK Kennel Club registered breeds were researched using systematic searches of existing databases. A set of inclusion and exclusion criteria, including an evidence strength scale (SEHB), were applied to search results. A total of 312 non-conformation linked inherited disorders was identified, with German shepherd dogs and Golden retrievers associated with the greatest number of disorders. The most commonly reported mode of inheritance was autosomal recessive (71%; 57 breed-disorder combinations), and the most common primarily affected body system was the nervous sensory system. To provide a true assessment of the scale of inherited disorders in the pedigree dogs studied more effort is required to collect accurate prevalence data.

AB - Recent debate concerning health problems in pedigree animals has highlighted gaps in current knowledge of the prevalence, severity and welfare implications of deleterious inherited traits within the pedigree dog population. In this second part of a two-part review, inherited disorders in the top 50 UK Kennel Club registered breeds were researched using systematic searches of existing databases. A set of inclusion and exclusion criteria, including an evidence strength scale (SEHB), were applied to search results. A total of 312 non-conformation linked inherited disorders was identified, with German shepherd dogs and Golden retrievers associated with the greatest number of disorders. The most commonly reported mode of inheritance was autosomal recessive (71%; 57 breed-disorder combinations), and the most common primarily affected body system was the nervous sensory system. To provide a true assessment of the scale of inherited disorders in the pedigree dogs studied more effort is required to collect accurate prevalence data.

U2 - 10.1016/j.tvjl.2009.11.002

DO - 10.1016/j.tvjl.2009.11.002

M3 - Article

VL - 183

SP - 39

EP - 45

JO - The Veterinary Journal

JF - The Veterinary Journal

SN - 1090-0233

IS - 1

ER -

Inherited defects in pedigree dogs. Part 2: Disorders that are not related to breed standards

Abstract

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this