Inhibition of the LSD1/KDM1 histone demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

T. Schenk; L. Howell; S. Gollner; P. Woster; L. Marton; R. Casero Jr; J. Dick; Ken Mills; A. Burnett; C. Muller-Tidow; K. Petrie; A. Zelent

doi:10.1038/nm.2661

Inhibition of the LSD1/KDM1 histone demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

T. Schenk, L. Howell, S. Gollner, P. Woster, L. Marton, R. Casero Jr, J. Dick, Ken Mills, A. Burnett, C. Muller-Tidow, K. Petrie, A. Zelent

Research output: Contribution to journal › Article › peer-review

464 Citations (Scopus)

Original language	English
Pages (from-to)	605-611
Number of pages	7
Journal	Nature Medicine
Volume	Online
Issue number	4
DOIs	https://doi.org/10.1038/nm.2661
Publication status	Published - Mar 2012

Bibliographical note

This paper involves the analysis of leukaemia patients with PLZF-RARa gene fusion - this is a rare disease and the paper includes data from 6 patients (representing all the UK patients) - this data was supplied by Mills. This paper continues studies published in 2007 in PNAS (cited 16 times)

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Access to Document

10.1038/nm.2661

Cite this

@article{c7e1eca967214faf801654094b632ac2,

title = "Inhibition of the LSD1/KDM1 histone demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia",

author = "T. Schenk and L. Howell and S. Gollner and P. Woster and L. Marton and {Casero Jr}, R. and J. Dick and Ken Mills and A. Burnett and C. Muller-Tidow and K. Petrie and A. Zelent",

note = "This paper involves the analysis of leukaemia patients with PLZF-RARa gene fusion - this is a rare disease and the paper includes data from 6 patients (representing all the UK patients) - this data was supplied by Mills. This paper continues studies published in 2007 in PNAS (cited 16 times)",

year = "2012",

month = mar,

doi = "10.1038/nm.2661",

language = "English",

volume = "Online",

pages = "605--611",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "4",

}

Inhibition of the LSD1/KDM1 histone demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia. / Schenk, T.; Howell, L.; Gollner, S.; Woster, P.; Marton, L.; Casero Jr, R.; Dick, J.; Mills, Ken; Burnett, A.; Muller-Tidow, C.; Petrie, K.; Zelent, A.

In: Nature Medicine, Vol. Online, No. 4, 03.2012, p. 605-611.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Inhibition of the LSD1/KDM1 histone demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

AU - Schenk, T.

AU - Howell, L.

AU - Gollner, S.

AU - Woster, P.

AU - Marton, L.

AU - Casero Jr, R.

AU - Dick, J.

AU - Mills, Ken

AU - Burnett, A.

AU - Muller-Tidow, C.

AU - Petrie, K.

AU - Zelent, A.

N1 - This paper involves the analysis of leukaemia patients with PLZF-RARa gene fusion - this is a rare disease and the paper includes data from 6 patients (representing all the UK patients) - this data was supplied by Mills. This paper continues studies published in 2007 in PNAS (cited 16 times)

PY - 2012/3

Y1 - 2012/3

U2 - 10.1038/nm.2661

DO - 10.1038/nm.2661

M3 - Article

VL - Online

SP - 605

EP - 611

JO - Nature Medicine

JF - Nature Medicine

SN - 1078-8956

IS - 4

ER -