Inhibition of the LSD1/KDM1 histone demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

T. Schenk, L. Howell, S. Gollner, P. Woster, L. Marton, R. Casero Jr, J. Dick, Ken Mills, A. Burnett, C. Muller-Tidow, K. Petrie, A. Zelent

Research output: Contribution to journalArticlepeer-review

545 Citations (Scopus)
Original languageEnglish
Pages (from-to)605-611
Number of pages7
JournalNature Medicine
Issue number4
Publication statusPublished - Mar 2012

Bibliographical note

This paper involves the analysis of leukaemia patients with PLZF-RARa gene fusion - this is a rare disease and the paper includes data from 6 patients (representing all the UK patients) - this data was supplied by Mills. This paper continues studies published in 2007 in PNAS (cited 16 times)

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine

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