Innate host defense functions of secretory leucoprotease inhibitor

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20 Citations (Scopus)

Abstract

Chronic lung diseases such as cystic fibrosis and emphysema are characterized by a protease burden, an infective process and a dominant proinflammatory profile. Secretory leucoprotease inhibitor (SLPI) is a prominent innate immune protein of the respiratory tract, possessing serine protease inhibitor activity, antibacterial activity, and anti-inflammatory/immunomodulatory activity. In the course of this review, the authors highlight the findings from a range of studies that illustrate the multiple functions of SLPI and its role in the resolution of the immune response.
Original languageEnglish
Pages (from-to)485-91
JournalExperimental Lung Research
Volume33
Issue number10
DOIs
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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