Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation

Jennifer L Kielczewski, Yagna P R Jarajapu, Evan L McFarland, Jun Cai, Aqeela Afzal, Sergio Li Calzi, Kyung Hee Chang, Todd Lydic, Lynn C Shaw, Julia Busik, Jeffrey Hughes, Arturo J Cardounel, Kenneth Wilson, Timothy J Lyons, Michael E Boulton, Robert N Mames, Tailoi Chan-Ling, Maria B Grant

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)


Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury.
Original languageEnglish
Pages (from-to)897-905
Number of pages9
JournalCirculation Research
Issue number9
Publication statusPublished - 23 Oct 2009


  • Animals
  • Animals, Newborn
  • Astrocytes
  • Cell Adhesion Molecules
  • Cell Death
  • Cell Movement
  • Cell Proliferation
  • Cells, Cultured
  • Ceramides
  • Cerebral Arteries
  • Cytoprotection
  • Disease Models, Animal
  • Endothelial Cells
  • Female
  • Gene Transfer Techniques
  • Green Fluorescent Proteins
  • Humans
  • Infant, Newborn
  • Insulin-Like Growth Factor Binding Protein 3
  • Male
  • Mesenteric Arteries
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Microfilament Proteins
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Phosphatidylinositol 3-Kinases
  • Phosphoproteins
  • Pregnancy
  • Proto-Oncogene Proteins c-akt
  • Rats
  • Rats, Sprague-Dawley
  • Retinal Neovascularization
  • Retinal Vessels
  • Retinopathy of Prematurity
  • Scavenger Receptors, Class B
  • Signal Transduction
  • Sphingomyelins
  • Stem Cells
  • Vasodilation


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