Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation

Jennifer L Kielczewski; Yagna P R Jarajapu; Evan L McFarland; Jun Cai; Aqeela Afzal; Sergio Li Calzi; Kyung Hee Chang; Todd Lydic; Lynn C Shaw; Julia Busik; Jeffrey Hughes; Arturo J Cardounel; Kenneth Wilson; Timothy J Lyons; Michael E Boulton; Robert N Mames; Tailoi Chan-Ling; Maria B Grant

doi:10.1161/CIRCRESAHA.109.199059

Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation

Jennifer L Kielczewski
, Yagna P R Jarajapu
, Evan L McFarland
, Jun Cai
, Aqeela Afzal
, Sergio Li Calzi
, Kyung Hee Chang
, Todd Lydic
, Lynn C Shaw
, Julia Busik
, Jeffrey Hughes
, Arturo J Cardounel
, Kenneth Wilson
, Timothy J Lyons
, Michael E Boulton
, Robert N Mames
, Tailoi Chan-Ling
, Maria B Grant

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

87 Citations (Scopus)

Abstract

Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury.

Original language	English
Pages (from-to)	897-905
Number of pages	9
Journal	Circulation Research
Volume	105
Issue number	9
DOIs	https://doi.org/10.1161/CIRCRESAHA.109.199059
Publication status	Published - 23 Oct 2009

Keywords

Animals
Animals, Newborn
Astrocytes
Cell Adhesion Molecules
Cell Death
Cell Movement
Cell Proliferation
Cells, Cultured
Ceramides
Cerebral Arteries
Cytoprotection
Disease Models, Animal
Endothelial Cells
Female
Gene Transfer Techniques
Green Fluorescent Proteins
Humans
Infant, Newborn
Insulin-Like Growth Factor Binding Protein 3
Male
Mesenteric Arteries
Mice
Mice, Inbred C57BL
Mice, Transgenic
Microfilament Proteins
Nitric Oxide
Nitric Oxide Synthase Type III
Phosphatidylinositol 3-Kinases
Phosphoproteins
Pregnancy
Proto-Oncogene Proteins c-akt
Rats
Rats, Sprague-Dawley
Retinal Neovascularization
Retinal Vessels
Retinopathy of Prematurity
Scavenger Receptors, Class B
Signal Transduction
Sphingomyelins
Stem Cells
Vasodilation

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10.1161/CIRCRESAHA.109.199059

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Kielczewski, J. L., Jarajapu, Y. P. R., McFarland, E. L., Cai, J., Afzal, A., Li Calzi, S., Chang, K. H., Lydic, T., Shaw, L. C., Busik, J., Hughes, J., Cardounel, A. J., Wilson, K., Lyons, T. J., Boulton, M. E., Mames, R. N., Chan-Ling, T., & Grant, M. B. (2009). Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation. Circulation Research, 105(9), 897-905. https://doi.org/10.1161/CIRCRESAHA.109.199059

@article{6c516f57ac3042c2a1ac8aca1dc04e3e,

title = "Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation",

abstract = "Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury.",

keywords = "Animals, Animals, Newborn, Astrocytes, Cell Adhesion Molecules, Cell Death, Cell Movement, Cell Proliferation, Cells, Cultured, Ceramides, Cerebral Arteries, Cytoprotection, Disease Models, Animal, Endothelial Cells, Female, Gene Transfer Techniques, Green Fluorescent Proteins, Humans, Infant, Newborn, Insulin-Like Growth Factor Binding Protein 3, Male, Mesenteric Arteries, Mice, Mice, Inbred C57BL, Mice, Transgenic, Microfilament Proteins, Nitric Oxide, Nitric Oxide Synthase Type III, Phosphatidylinositol 3-Kinases, Phosphoproteins, Pregnancy, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Retinal Neovascularization, Retinal Vessels, Retinopathy of Prematurity, Scavenger Receptors, Class B, Signal Transduction, Sphingomyelins, Stem Cells, Vasodilation",

author = "Kielczewski, \{Jennifer L\} and Jarajapu, \{Yagna P R\} and McFarland, \{Evan L\} and Jun Cai and Aqeela Afzal and \{Li Calzi\}, Sergio and Chang, \{Kyung Hee\} and Todd Lydic and Shaw, \{Lynn C\} and Julia Busik and Jeffrey Hughes and Cardounel, \{Arturo J\} and Kenneth Wilson and Lyons, \{Timothy J\} and Boulton, \{Michael E\} and Mames, \{Robert N\} and Tailoi Chan-Ling and Grant, \{Maria B\}",

year = "2009",

month = oct,

day = "23",

doi = "10.1161/CIRCRESAHA.109.199059",

language = "English",

volume = "105",

pages = "897--905",

journal = "Circulation Research",

issn = "0009-7330",

publisher = "Lippincott Williams and Wilkins",

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Kielczewski, JL, Jarajapu, YPR, McFarland, EL, Cai, J, Afzal, A, Li Calzi, S, Chang, KH, Lydic, T, Shaw, LC, Busik, J, Hughes, J, Cardounel, AJ, Wilson, K, Lyons, TJ, Boulton, ME, Mames, RN, Chan-Ling, T & Grant, MB 2009, 'Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation', Circulation Research, vol. 105, no. 9, pp. 897-905. https://doi.org/10.1161/CIRCRESAHA.109.199059

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AU - Kielczewski, Jennifer L

AU - Jarajapu, Yagna P R

AU - McFarland, Evan L

AU - Cai, Jun

AU - Afzal, Aqeela

AU - Li Calzi, Sergio

AU - Chang, Kyung Hee

AU - Lydic, Todd

AU - Shaw, Lynn C

AU - Busik, Julia

AU - Hughes, Jeffrey

AU - Cardounel, Arturo J

AU - Wilson, Kenneth

AU - Lyons, Timothy J

AU - Boulton, Michael E

AU - Mames, Robert N

AU - Chan-Ling, Tailoi

AU - Grant, Maria B

PY - 2009/10/23

Y1 - 2009/10/23

N2 - Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury.

AB - Insulin-like growth factor binding protein (IGFBP)-3 modulates vascular development by regulating endothelial progenitor cell (EPC) behavior, specifically stimulating EPC cell migration. This study was undertaken to investigate the mechanism of IGFBP-3 effects on EPC function and how IGFBP-3 mediates cytoprotection following vascular injury.

KW - Animals

KW - Animals, Newborn

KW - Astrocytes

KW - Cell Adhesion Molecules

KW - Cell Death

KW - Cell Movement

KW - Cell Proliferation

KW - Cells, Cultured

KW - Ceramides

KW - Cerebral Arteries

KW - Cytoprotection

KW - Disease Models, Animal

KW - Endothelial Cells

KW - Female

KW - Gene Transfer Techniques

KW - Green Fluorescent Proteins

KW - Humans

KW - Infant, Newborn

KW - Insulin-Like Growth Factor Binding Protein 3

KW - Male

KW - Mesenteric Arteries

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Microfilament Proteins

KW - Nitric Oxide

KW - Nitric Oxide Synthase Type III

KW - Phosphatidylinositol 3-Kinases

KW - Phosphoproteins

KW - Pregnancy

KW - Proto-Oncogene Proteins c-akt

KW - Rats

KW - Rats, Sprague-Dawley

KW - Retinal Neovascularization

KW - Retinal Vessels

KW - Retinopathy of Prematurity

KW - Scavenger Receptors, Class B

KW - Signal Transduction

KW - Sphingomyelins

KW - Stem Cells

KW - Vasodilation

U2 - 10.1161/CIRCRESAHA.109.199059

DO - 10.1161/CIRCRESAHA.109.199059

M3 - Article

C2 - 19762684

SN - 0009-7330

VL - 105

SP - 897

EP - 905

JO - Circulation Research

JF - Circulation Research

IS - 9

ER -

Insulin-like growth factor binding protein-3 mediates vascular repair by enhancing nitric oxide generation

Abstract

Keywords

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