Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.

Karl Butterworth, Mihaela Ghita, Kathryn Brown, Olivia Kelada, Edward E Graves

Research output: Contribution to journal › Review article

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Abstract

Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects of the clinical scenario in radiation oncology is critical to translational success. The use of small animal irradiators with disease relevant mouse models and advanced in vivo imaging approaches offers unique possibilities to interrogate the radiotherapy response of tumors and normal tissues with high potential to translate to improvements in clinical outcomes. The present review highlights the current technology and applications of small animal irradiators, and explores how these can be combined with molecular and functional imaging in advanced preclinical radiotherapy research.
Original languageEnglish
JournalCancers
Volume11
Issue number2
DOIs
Publication statusPublished - 02 Feb 2019

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Radiotherapy
Biological Models
Radiation Oncology
Molecular Imaging
Translational Medical Research
Research
Technology
Neoplasms
Therapeutics

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Butterworth, Karl ; Ghita, Mihaela ; Brown, Kathryn ; Kelada, Olivia ; Graves, Edward E. / Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research. In: Cancers. 2019 ; Vol. 11, No. 2.
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title = "Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.",
abstract = "Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects of the clinical scenario in radiation oncology is critical to translational success. The use of small animal irradiators with disease relevant mouse models and advanced in vivo imaging approaches offers unique possibilities to interrogate the radiotherapy response of tumors and normal tissues with high potential to translate to improvements in clinical outcomes. The present review highlights the current technology and applications of small animal irradiators, and explores how these can be combined with molecular and functional imaging in advanced preclinical radiotherapy research.",
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doi = "10.3390/cancers11020170",
language = "English",
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Butterworth, K, Ghita, M, Brown, K, Kelada, O & Graves, EE 2019, 'Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.', Cancers, vol. 11, no. 2. https://doi.org/10.3390/cancers11020170

Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research. / Butterworth, Karl; Ghita, Mihaela; Brown, Kathryn; Kelada, Olivia; Graves, Edward E.

In: Cancers, Vol. 11, No. 2, 02.02.2019.

Research output: Contribution to journal › Review article

TY - JOUR

T1 - Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research.

AU - Butterworth, Karl

AU - Ghita, Mihaela

AU - Brown, Kathryn

AU - Kelada, Olivia

AU - Graves, Edward E

PY - 2019/2/2

Y1 - 2019/2/2

N2 - Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects of the clinical scenario in radiation oncology is critical to translational success. The use of small animal irradiators with disease relevant mouse models and advanced in vivo imaging approaches offers unique possibilities to interrogate the radiotherapy response of tumors and normal tissues with high potential to translate to improvements in clinical outcomes. The present review highlights the current technology and applications of small animal irradiators, and explores how these can be combined with molecular and functional imaging in advanced preclinical radiotherapy research.

AB - Translational research aims to provide direct support for advancing novel treatment approaches in oncology towards improving patient outcomes. Preclinical studies have a central role in this process and the ability to accurately model biological and physical aspects of the clinical scenario in radiation oncology is critical to translational success. The use of small animal irradiators with disease relevant mouse models and advanced in vivo imaging approaches offers unique possibilities to interrogate the radiotherapy response of tumors and normal tissues with high potential to translate to improvements in clinical outcomes. The present review highlights the current technology and applications of small animal irradiators, and explores how these can be combined with molecular and functional imaging in advanced preclinical radiotherapy research.

U2 - 10.3390/cancers11020170

DO - 10.3390/cancers11020170

M3 - Review article

VL - 11

JO - Cancers

JF - Cancers

SN - 2072-6694

IS - 2

ER -

Butterworth K, Ghita M, Brown K, Kelada O, Graves EE. Integrating Small Animal Irradiators with Functional Imaging for Advanced Preclinical Radiotherapy Research. Cancers. 2019 Feb 2;11(2). https://doi.org/10.3390/cancers11020170

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