Intensity-modulated radiotherapy reduces lung irradiation in patients with carcinoma of the oesophagus.

C.M. Nutting; J.L. Bedford; V Cosgrove; D.M. Tait; D.P. Dearnaley; S. Webb

doi:10.1159/000061308

Intensity-modulated radiotherapy reduces lung irradiation in patients with carcinoma of the oesophagus.

C.M. Nutting, J.L. Bedford, V Cosgrove, D.M. Tait, D.P. Dearnaley, S. Webb

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The 2-year survival rate after conventional radiotherapy for carcinoma of the oesophagus is around 10–20% [8]. Concomitant chemoradiation schedules have produced survival figures of 25–30% at 5 years, and this is now considered standard treatment [1]. Conformal radiotherapy techniques offer the potential to deliver higher doses of radiation to oesophageal tumours [5], and this may improve local tumour control. However, concerns regarding late normal tissue damage to the lung parenchyma and spinal cord remain a concern. Intensitymodulated radiotherapy (IMRT) allows complex dose distributions to be produced, and can reduce the dose to radiosensitive organs close to the tumour [2]. The present study was designed to investigate the impact of beam intensity modulation on treatment planning for carcinoma of the oesophagus, by comparing a standard three-dimensional conformal radiotherapy (3DCRT) technique to an IMRT technique using the same number and orientation of treatment fields.

Original language	English
Pages (from-to)	128-131
Number of pages	4
Journal	Frontiers of Radiation Therapy and Oncology
Volume	37
DOIs	https://doi.org/10.1159/000061308
Publication status	Published - 2002

ASJC Scopus subject areas

General Medicine
Oncology
Radiology Nuclear Medicine and imaging

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title = "Intensity-modulated radiotherapy reduces lung irradiation in patients with carcinoma of the oesophagus.",

abstract = "The 2-year survival rate after conventional radiotherapy for carcinoma of the oesophagus is around 10–20% [8]. Concomitant chemoradiation schedules have produced survival figures of 25–30% at 5 years, and this is now considered standard treatment [1]. Conformal radiotherapy techniques offer the potential to deliver higher doses of radiation to oesophageal tumours [5], and this may improve local tumour control. However, concerns regarding late normal tissue damage to the lung parenchyma and spinal cord remain a concern. Intensitymodulated radiotherapy (IMRT) allows complex dose distributions to be produced, and can reduce the dose to radiosensitive organs close to the tumour [2]. The present study was designed to investigate the impact of beam intensity modulation on treatment planning for carcinoma of the oesophagus, by comparing a standard three-dimensional conformal radiotherapy (3DCRT) technique to an IMRT technique using the same number and orientation of treatment fields.",

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T1 - Intensity-modulated radiotherapy reduces lung irradiation in patients with carcinoma of the oesophagus.

AU - Nutting, C.M.

AU - Bedford, J.L.

AU - Cosgrove, V

AU - Tait, D.M.

AU - Dearnaley, D.P.

AU - Webb, S.

PY - 2002

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N2 - The 2-year survival rate after conventional radiotherapy for carcinoma of the oesophagus is around 10–20% [8]. Concomitant chemoradiation schedules have produced survival figures of 25–30% at 5 years, and this is now considered standard treatment [1]. Conformal radiotherapy techniques offer the potential to deliver higher doses of radiation to oesophageal tumours [5], and this may improve local tumour control. However, concerns regarding late normal tissue damage to the lung parenchyma and spinal cord remain a concern. Intensitymodulated radiotherapy (IMRT) allows complex dose distributions to be produced, and can reduce the dose to radiosensitive organs close to the tumour [2]. The present study was designed to investigate the impact of beam intensity modulation on treatment planning for carcinoma of the oesophagus, by comparing a standard three-dimensional conformal radiotherapy (3DCRT) technique to an IMRT technique using the same number and orientation of treatment fields.

AB - The 2-year survival rate after conventional radiotherapy for carcinoma of the oesophagus is around 10–20% [8]. Concomitant chemoradiation schedules have produced survival figures of 25–30% at 5 years, and this is now considered standard treatment [1]. Conformal radiotherapy techniques offer the potential to deliver higher doses of radiation to oesophageal tumours [5], and this may improve local tumour control. However, concerns regarding late normal tissue damage to the lung parenchyma and spinal cord remain a concern. Intensitymodulated radiotherapy (IMRT) allows complex dose distributions to be produced, and can reduce the dose to radiosensitive organs close to the tumour [2]. The present study was designed to investigate the impact of beam intensity modulation on treatment planning for carcinoma of the oesophagus, by comparing a standard three-dimensional conformal radiotherapy (3DCRT) technique to an IMRT technique using the same number and orientation of treatment fields.

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Intensity-modulated radiotherapy reduces lung irradiation in patients with carcinoma of the oesophagus.

Abstract

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