@inbook{86cb3baa3c814018bf8f539959f719b5,
title = "Interaction between Sars-CoV-2 structural proteins and host cellular receptors: from basic mechanisms to clinical perspectives",
abstract = "Severe acute respiratory syndrome coronavirus 2 (Sars-CoV-2) has caused a global pandemic that has affected the lives of billions of individuals. Sars-CoV-2 primarily infects human cells by binding of the viral spike protein to angiotensin-converting enzyme 2 (ACE2). In addition, novel means of viral entry are currently being investigated, including Neuropillin 1, toll-like receptors (TLRs), cluster of differentiation 147 (CD147), and integrin α5β1. Enriched expression of these proteins across metabolic regulatory organs/tissues, including the circulatory system, liver, pancreas, and intestine contributes to major clinical complications among COVID-19 patients, particularly the development of hypertension, myocardial injury, arrhythmia, acute coronary syndrome and increased coagulation in the circulatory system during and post-infection. Pre-existing metabolic disease, such as cardiovascular disease, obesity, diabetes, and non-alcoholic fatty liver disease, is associated with increased risk of hospitalization, persistent post-infection complications and worse outcomes in patients with COVID-19. This review overviews the biological features of Sars-CoV-2, highlights recent findings that delineate the pathological mechanisms of COVID-19 and the consequent clinical diseases.",
keywords = "Peptidyl-Dipeptidase A - metabolism, Cardiovascular disease, Cytokine storm, Cardiovascular Diseases, NAFLD, Sars-CoV-2, Hypertension, ACE2, Humans, Diabetes, SARS-CoV-2, COVID-19",
author = "Henry Wade and Qihua Duan and Qiaozhu Su",
year = "2022",
month = sep,
day = "7",
doi = "10.1016/bs.apcsb.2022.05.010",
language = "English",
isbn = "9780323997805",
series = "Advances in Protein Chemistry and Structural Biology",
publisher = "Elsevier Inc.",
pages = "243--277",
editor = "Donev, { Rossen }",
booktitle = "Disorders of protein synthesis",
address = "United States",
}