Interactions of a non-thermal atmospheric pressure plasma effluent with PC-3 prostate cancer cells

Andrew Gibson, Helen O. McCarthy, Ahlam Ali, Deborah O'Connell, William G. Graham

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The effect of a radio-frequency driven, microscale non thermal atmospheric pressure plasma jet operated in helium with vol. 0.3% molecular oxygen gas admixture, on PC-3 prostate cancer cells has been investigated. The viability of cells exposed to the plasma was found to decrease with increasing plasma exposure time, with apoptosis through caspase and PARP cleavage being observed. High concentrations of nitrite and nitrate were detected in growth media exposed to the plasma and were found to increase in a time dependent manner post exposure. This indicates a slow release of reactive nitrogen species into the growth media, which is likely to influence cellular response to plasma exposure.

Original languageEnglish
Pages (from-to)1142-1149
Number of pages8
JournalPlasma Processes and Polymers
Volume11
Issue number12
Early online date12 Sep 2014
DOIs
Publication statusPublished - Dec 2014

Keywords

  • Apoptosis
  • Cancer
  • Nitric oxide
  • Plasma jet
  • Radicals

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Polymers and Plastics

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