Intercellular Communication via Organelle Transfer in the Biology and Therapeutic Applications of Stem Cells

Lisa MA Murray, Anna D Krasnodembskaya

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Abstract

The therapeutic potential of stem cell‐based therapies may be largely dependent on the ability of stem cells to modulate host cells rather than on their differentiation into host tissues. Within the last decade, there has been considerable interest in the inter‐cellular communication mediated by the transfer of cytoplasmic material and organelles between cells. Numerous studies have shown that mitochondria and lysosomes are transported between cells by various mechanisms, such as tunnelling nanotubes, microvesicles and cellular fusion. This review will focus on the known instances of organelle transfer between stem cells and differentiated cells, what effects it has on recipient cells and how organelle transfer is regulated.
Original languageEnglish
Pages (from-to)14-25
JournalStem Cells
Volume37
Issue number1
Early online date17 Nov 2018
DOIs
Publication statusPublished - 01 Jan 2019

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Bibliographical note

Author contribution: Senior Author. In this Review we discuss the state of the art in the field of intercellular communication mediated by on organelle transfer between stem and somatic cells. Better understanding of this phenomenon is important for the development of new therapeutic strategies based on the concept of stem cell‐derived organelle transplantation. I contributed to the design, manuscript writing and final approval of the manuscript. Stem cells, 91% (7/76) IF 5.56, SNIP 1.383

Keywords

  • Cellular fusion
  • Extracellular vesicles
  • Intercellular communication
  • Lysosomes
  • Mitochondria
  • Organelle transfer
  • Stem cells
  • Tunneling nanotubules

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