Interface chirality: from biological effects to biomedical applications

Liting Guo, Yanqiu Guo, Rui Wang, Jie Feng, Nannan Shao, Xiaolin Zhou, Yunlong Zhou

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
45 Downloads (Pure)

Abstract

Chiral surface is a critical mediator that significantly impacts interaction with biological systems on regulating cell behavior. To better understand how the properties of interfacial Chirality affect cell behavior and address the limitations of chiral materials for biomedical applications, in this review, we mainly focus on the recent developments of chiral bio-interfaces for the controllable and accurate guidance of chiral biomedical phenomena. In particular, we will discuss how cells or organisms sense and respond to the chiral stimulus, as well as the chirality mediating cell fate, tissue repair, and organism immune response will be reviewed. In addition, the biological applications of chirality, such as drug delivery, antibacterial, antivirus and antitumor activities, and biological signal detection, will also be reviewed. Finally, the challenges of chiral bio-interfaces for controlling biological response and the further application of interface chirality materials for biomedical will be discussed.

Original languageEnglish
Article number5629
Number of pages18
JournalMolecules
Volume28
Issue number15
Early online date25 Jul 2023
DOIs
Publication statusPublished - 01 Aug 2023

Bibliographical note

Funding Information:
This research was funded by the National Natural Science Foundation of China (Grant No. 21773172), Research Center of Clinical Functional Materials (WIUCASQD 2019001), Diagnosis & Treatment Devices of Zhejiang Province (WIBEK181006), Major Science and Technology Project of Wenzhou Science and Technology (ZG2022017), and Public Welfare Science and Technology Plan of Wenzhou (Y2020237 and Y20210043).

Publisher Copyright:
© 2023 by the authors.

Keywords

  • Chemistry (miscellaneous)
  • Analytical Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Molecular Medicine
  • Drug Discovery
  • Pharmaceutical Science

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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