Abstract
Chiral surface is a critical mediator that significantly impacts interaction with biological systems on regulating cell behavior. To better understand how the properties of interfacial Chirality affect cell behavior and address the limitations of chiral materials for biomedical applications, in this review, we mainly focus on the recent developments of chiral bio-interfaces for the controllable and accurate guidance of chiral biomedical phenomena. In particular, we will discuss how cells or organisms sense and respond to the chiral stimulus, as well as the chirality mediating cell fate, tissue repair, and organism immune response will be reviewed. In addition, the biological applications of chirality, such as drug delivery, antibacterial, antivirus and antitumor activities, and biological signal detection, will also be reviewed. Finally, the challenges of chiral bio-interfaces for controlling biological response and the further application of interface chirality materials for biomedical will be discussed.
Original language | English |
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Article number | 5629 |
Number of pages | 18 |
Journal | Molecules |
Volume | 28 |
Issue number | 15 |
Early online date | 25 Jul 2023 |
DOIs | |
Publication status | Published - 01 Aug 2023 |
Bibliographical note
Funding Information:This research was funded by the National Natural Science Foundation of China (Grant No. 21773172), Research Center of Clinical Functional Materials (WIUCASQD 2019001), Diagnosis & Treatment Devices of Zhejiang Province (WIBEK181006), Major Science and Technology Project of Wenzhou Science and Technology (ZG2022017), and Public Welfare Science and Technology Plan of Wenzhou (Y2020237 and Y20210043).
Publisher Copyright:
© 2023 by the authors.
Keywords
- Chemistry (miscellaneous)
- Analytical Chemistry
- Organic Chemistry
- Physical and Theoretical Chemistry
- Molecular Medicine
- Drug Discovery
- Pharmaceutical Science
ASJC Scopus subject areas
- Analytical Chemistry
- Chemistry (miscellaneous)
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Physical and Theoretical Chemistry
- Organic Chemistry