International trends in oesophageal cancer survival by histological subtype between 1995 and 2014

Eileen Morgan; Isabelle Soerjomataram; Anna T Gavin; Mark J Rutherford; Piers Gatenby; Aude Bardot; Jacques Ferlay; Oliver Bucher; Prithwish De; Gerda Engholm; Christopher Jackson; Serena Kozie; Alana Little; Bjorn Møller; Lorraine Shack; Hanna Tervonen; Vicky Thursfield; Sally Vernon; Paul M Walsh; Ryan R Woods; Christian Finley; Neil Merrett; Dianne L O'Connell; John V Reynolds; Freddie Bray; Melina Arnold

doi:10.1136/gutjnl-2020-321089

International trends in oesophageal cancer survival by histological subtype between 1995 and 2014

Eileen Morgan, Isabelle Soerjomataram, Anna T Gavin, Mark J Rutherford, Piers Gatenby, Aude Bardot, Jacques Ferlay, Oliver Bucher, Prithwish De, Gerda Engholm, Christopher Jackson, Serena Kozie, Alana Little, Bjorn Møller, Lorraine Shack, Hanna Tervonen, Vicky Thursfield, Sally Vernon, Paul M Walsh, Ryan R WoodsChristian Finley, Neil Merrett, Dianne L O'Connell, John V Reynolds, Freddie Bray, Melina Arnold

Queen's University Belfast

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Abstract

INTRODUCTION: Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC).

METHODS: The ICBP SURVMARK-2 project, a platform for international comparisons of cancer survival, collected cases of oesophageal cancer diagnosed 1995 to 2014, followed until 31st December 2015, from cancer registries covering seven participating countries with similar access to healthcare (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK). 1-year and 3-year age-standardised net survival alongside incidence rates were calculated by country, subtype, sex, age group and period of diagnosis.

RESULTS: 111 894 cases of AC and 73 408 cases of SCC were included in the analysis. Marked improvements in survival were observed over the 20-year period in each country, particularly for AC, younger age groups and 1 year after diagnosis. Survival was consistently higher for both subtypes in Australia and Ireland followed by Norway, Denmark, New Zealand, the UK and Canada. During 2010 to 2014, survival was higher for AC compared with SCC, with 1-year survival ranging from 46.9% (Canada) to 54.4% (Ireland) for AC and 39.6% (Denmark) to 53.1% (Australia) for SCC.

CONCLUSION: Marked improvements in both oesophageal AC and SCC survival suggest advances in treatment. Less marked improvements 3 years after diagnosis, among older age groups and patients with SCC, highlight the need for further advances in early detection and treatment of oesophageal cancer alongside primary prevention to reduce the overall burden from the disease.

Original language	English
Journal	Gut
Early online date	17 Jun 2020
DOIs	https://doi.org/10.1136/gutjnl-2020-321089
Publication status	Early online date - 17 Jun 2020

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International trends in oesophageal cancer survival by histological subtype between 1995 and 2014
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Morgan, E., Soerjomataram, I., Gavin, A. T., Rutherford, M. J., Gatenby, P., Bardot, A., Ferlay, J., Bucher, O., De, P., Engholm, G., Jackson, C., Kozie, S., Little, A., Møller, B., Shack, L., Tervonen, H., Thursfield, V., Vernon, S., Walsh, P. M., ... Arnold, M. (2020). International trends in oesophageal cancer survival by histological subtype between 1995 and 2014. Gut. Advance online publication. https://doi.org/10.1136/gutjnl-2020-321089

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title = "International trends in oesophageal cancer survival by histological subtype between 1995 and 2014",

abstract = "INTRODUCTION: Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC).METHODS: The ICBP SURVMARK-2 project, a platform for international comparisons of cancer survival, collected cases of oesophageal cancer diagnosed 1995 to 2014, followed until 31st December 2015, from cancer registries covering seven participating countries with similar access to healthcare (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK). 1-year and 3-year age-standardised net survival alongside incidence rates were calculated by country, subtype, sex, age group and period of diagnosis.RESULTS: 111 894 cases of AC and 73 408 cases of SCC were included in the analysis. Marked improvements in survival were observed over the 20-year period in each country, particularly for AC, younger age groups and 1 year after diagnosis. Survival was consistently higher for both subtypes in Australia and Ireland followed by Norway, Denmark, New Zealand, the UK and Canada. During 2010 to 2014, survival was higher for AC compared with SCC, with 1-year survival ranging from 46.9% (Canada) to 54.4% (Ireland) for AC and 39.6% (Denmark) to 53.1% (Australia) for SCC.CONCLUSION: Marked improvements in both oesophageal AC and SCC survival suggest advances in treatment. Less marked improvements 3 years after diagnosis, among older age groups and patients with SCC, highlight the need for further advances in early detection and treatment of oesophageal cancer alongside primary prevention to reduce the overall burden from the disease.",

author = "Eileen Morgan and Isabelle Soerjomataram and Gavin, {Anna T} and Rutherford, {Mark J} and Piers Gatenby and Aude Bardot and Jacques Ferlay and Oliver Bucher and Prithwish De and Gerda Engholm and Christopher Jackson and Serena Kozie and Alana Little and Bjorn M{\o}ller and Lorraine Shack and Hanna Tervonen and Vicky Thursfield and Sally Vernon and Walsh, {Paul M} and Woods, {Ryan R} and Christian Finley and Neil Merrett and O'Connell, {Dianne L} and Reynolds, {John V} and Freddie Bray and Melina Arnold",

note = "{\textcopyright} Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.",

year = "2020",

month = jun,

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doi = "10.1136/gutjnl-2020-321089",

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Morgan, E, Soerjomataram, I, Gavin, AT, Rutherford, MJ, Gatenby, P, Bardot, A, Ferlay, J, Bucher, O, De, P, Engholm, G, Jackson, C, Kozie, S, Little, A, Møller, B, Shack, L, Tervonen, H, Thursfield, V, Vernon, S, Walsh, PM, Woods, RR, Finley, C, Merrett, N, O'Connell, DL, Reynolds, JV, Bray, F & Arnold, M 2020, 'International trends in oesophageal cancer survival by histological subtype between 1995 and 2014', Gut. https://doi.org/10.1136/gutjnl-2020-321089

TY - JOUR

T1 - International trends in oesophageal cancer survival by histological subtype between 1995 and 2014

AU - Morgan, Eileen

AU - Soerjomataram, Isabelle

AU - Gavin, Anna T

AU - Rutherford, Mark J

AU - Gatenby, Piers

AU - Bardot, Aude

AU - Ferlay, Jacques

AU - Bucher, Oliver

AU - De, Prithwish

AU - Engholm, Gerda

AU - Jackson, Christopher

AU - Kozie, Serena

AU - Little, Alana

AU - Møller, Bjorn

AU - Shack, Lorraine

AU - Tervonen, Hanna

AU - Thursfield, Vicky

AU - Vernon, Sally

AU - Walsh, Paul M

AU - Woods, Ryan R

AU - Finley, Christian

AU - Merrett, Neil

AU - O'Connell, Dianne L

AU - Reynolds, John V

AU - Bray, Freddie

AU - Arnold, Melina

PY - 2020/6/17

Y1 - 2020/6/17

N2 - INTRODUCTION: Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC).METHODS: The ICBP SURVMARK-2 project, a platform for international comparisons of cancer survival, collected cases of oesophageal cancer diagnosed 1995 to 2014, followed until 31st December 2015, from cancer registries covering seven participating countries with similar access to healthcare (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK). 1-year and 3-year age-standardised net survival alongside incidence rates were calculated by country, subtype, sex, age group and period of diagnosis.RESULTS: 111 894 cases of AC and 73 408 cases of SCC were included in the analysis. Marked improvements in survival were observed over the 20-year period in each country, particularly for AC, younger age groups and 1 year after diagnosis. Survival was consistently higher for both subtypes in Australia and Ireland followed by Norway, Denmark, New Zealand, the UK and Canada. During 2010 to 2014, survival was higher for AC compared with SCC, with 1-year survival ranging from 46.9% (Canada) to 54.4% (Ireland) for AC and 39.6% (Denmark) to 53.1% (Australia) for SCC.CONCLUSION: Marked improvements in both oesophageal AC and SCC survival suggest advances in treatment. Less marked improvements 3 years after diagnosis, among older age groups and patients with SCC, highlight the need for further advances in early detection and treatment of oesophageal cancer alongside primary prevention to reduce the overall burden from the disease.

AB - INTRODUCTION: Survival from oesophageal cancer remains poor, even across high-income countries. Ongoing changes in the epidemiology of the disease highlight the need for survival assessments by its two main histological subtypes, adenocarcinoma (AC) and squamous cell carcinoma (SCC).METHODS: The ICBP SURVMARK-2 project, a platform for international comparisons of cancer survival, collected cases of oesophageal cancer diagnosed 1995 to 2014, followed until 31st December 2015, from cancer registries covering seven participating countries with similar access to healthcare (Australia, Canada, Denmark, Ireland, New Zealand, Norway and the UK). 1-year and 3-year age-standardised net survival alongside incidence rates were calculated by country, subtype, sex, age group and period of diagnosis.RESULTS: 111 894 cases of AC and 73 408 cases of SCC were included in the analysis. Marked improvements in survival were observed over the 20-year period in each country, particularly for AC, younger age groups and 1 year after diagnosis. Survival was consistently higher for both subtypes in Australia and Ireland followed by Norway, Denmark, New Zealand, the UK and Canada. During 2010 to 2014, survival was higher for AC compared with SCC, with 1-year survival ranging from 46.9% (Canada) to 54.4% (Ireland) for AC and 39.6% (Denmark) to 53.1% (Australia) for SCC.CONCLUSION: Marked improvements in both oesophageal AC and SCC survival suggest advances in treatment. Less marked improvements 3 years after diagnosis, among older age groups and patients with SCC, highlight the need for further advances in early detection and treatment of oesophageal cancer alongside primary prevention to reduce the overall burden from the disease.

U2 - 10.1136/gutjnl-2020-321089

DO - 10.1136/gutjnl-2020-321089

M3 - Article

C2 - 32554620

SN - 0017-5749

JO - Gut

JF - Gut

ER -

International trends in oesophageal cancer survival by histological subtype between 1995 and 2014

Abstract

Bibliographical note

UN SDGs

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