Interventions for pancreatitis-new approaches, knowledge gaps, and research opportunities. Summary of a National Institute of Diabetes and Digestive and Kidney Diseases workshop

Anna Evans Phillips, Steven J Hughes, Dana K Andersen, Adam Bell, Randall Brand, Gregory A Coté, Adriana Cowdin, Nancy Diazgranados, Vikas Dudeja, Sinead N Duggan, Evan Fogel, Chris E Forsmark, A Jay Freeman, George Gittes, Phil A Hart, Christie Jeon, William Nealon, John Neoptolemos, Tonya M Palermo, Stephen PandolKristen M Roberts, Martin Rosenthal, Vikesh K Singh, Dhiraj Yadav, David C Whitcomb, Nicholas Zyromski

Research output: Contribution to journalArticlepeer-review

Abstract

There exists no cure for acute, recurrent acute or chronic pancreatitis and treatments to date have been focused on managing symptoms. A recent workshop held by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) focused on interventions that might disrupt or perhaps even reverse the natural course of this heterogenous disease, aiming to identify knowledge gaps and research opportunities that might inform future funding initiatives for NIDDK. The breadth and variety of identified active or planned clinical trials traverses the spectrum of the disease and was conceptually grouped for the workshop into behavioral, nutritional, pharmacologic and biologic, and mechanical interventions. Cognitive and other behavioral therapies are proven interventions for pain and addiction, but barriers exist to their use. Whilst a disease specific instrument quantifying pain is now validated, an equivalent is lacking for nutrition - and both face challenges in ease and frequency of administration. Multiple pharmacologic agents hold promise. Ongoing development of Patient Reported Outcome (PRO) measurements can satisfy Investigative New Drug (IND) regulatory assessments. Despite multiple randomized clinical trials demonstrating benefit, great uncertainty remains regarding patient selection, timing of intervention, and type of mechanical intervention (endoscopic versus surgery). Challenges and opportunities to establish beneficial interventions for patients were identified.

Original languageEnglish
Pages (from-to)e368-e377
JournalPancreas
Volume53
Issue number4
Early online date26 Mar 2024
DOIs
Publication statusPublished - 01 Apr 2024
Externally publishedYes

Bibliographical note

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

  • United States
  • Humans
  • National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
  • Pancreatitis, Chronic/therapy
  • Pain
  • Diabetes Mellitus/diagnosis

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