Intracellular survival of Burkholderia cepacia complex in phagocytic cells

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Burkholderia cepacia complex (Bcc) species are a group of Gram-negative opportunistic pathogens that infect the airways of cystic fibrosis patients, and occasionally they infect other immunocompromised patients. Bcc bacteria display high-level multidrug resistance, and chronically persist in the infected host while eliciting robust inflammatory responses. Studies using macrophages, neutrophils and dendritic cells, combined with advances to genetically manipulate these bacteria have increased our understanding of the molecular mechanisms of virulence in these pathogens and the molecular details of cell-host responses triggering inflammation. This article discusses our current view of the intracellular survival of B. cenocepacia within macrophages.
Original languageEnglish
Pages (from-to)607-615
Number of pages9
JournalCanadian Journal of Microbiology
Issue number9
Early online date30 Jun 2015
Publication statusPublished - Sep 2015


  • Burkholderia cepacia complex
  • Cystic Fibrosis
  • Macrophages
  • intracellular survival
  • inflammation
  • Type 6 Secretion systems


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