Intradermal and transdermal drug delivery using microneedles – Fabrication, performance evaluation and application to lymphatic delivery

Akmal Hidayat Bin Sabri, Yujin Kim, Maria Marlow, David J. Scurr, Joel Segal, Ajay K. Banga, Leonid Kagan, Jong Bong Lee

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The progress in microneedle research is evidenced by the transition from simple ‘poke and patch’ solid microneedles fabricated from silicon and stainless steel to the development of bioresponsive systems such as hydrogel-forming and dissolving microneedles. In this review, we provide an outline on various microneedle fabrication techniques which are currently employed. As a range of factors, including materials, geometry and design of the microneedles, affect the performance, it is important to understand the relationships between them and the resulting delivery of therapeutics. Accordingly, there is a need for appropriate methodologies and techniques for characterization and evaluation of microneedle performance, which will also be discussed. As the research expands, it has been observed that therapeutics delivered via microneedles has gained expedited access to the lymphatics, which makes them a favorable delivery method for targeting the lymphatic system. Such opportunity is valuable in the area of vaccination and treatment of lymphatic disorders, which is the final focus of the review.
Original languageEnglish
Pages (from-to)195-215
Number of pages21
JournalAdvanced Drug Delivery Reviews
Volume153
Early online date18 Oct 2019
DOIs
Publication statusPublished - 01 Jan 2020

Keywords

  • Microneedle characterization
  • biomedical device
  • chemotherapeutics
  • dermal lymphatics
  • immunomodulation
  • macromolecule delivery
  • microfabrication
  • performance assessment
  • skin
  • vaccination

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