Investigation of influence of process variables on mechanical strength, size and homogeneity of pharmaceutical granules produced by fluidised hot melt granulation

Chirangano Mangwandi; N. A. Zainal; Liu JiangTao; Y. Glocheux; Ahmad B. Albadarin

doi:10.1016/j.powtec.2014.11.042

Investigation of influence of process variables on mechanical strength, size and homogeneity of pharmaceutical granules produced by fluidised hot melt granulation

Chirangano Mangwandi^*, N. A. Zainal, Liu JiangTao, Y. Glocheux, Ahmad B. Albadarin

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

423 Downloads (Pure)

Abstract

The overall aim of the project was to study the influence of process variables on the distribution of a model active pharmaceutical ingredient (API) during fluidised melt granulation of pharmaceutical granules with a view of optimising product characteristics. Granules were produced using common pharmaceutical excipients; lactose monohydrate using poly ethylene glycol (PEG1500) as a meltable binder. Methylene blue was used as a model API. Empirical models relating the process variables to the granules properties such as granule mean size, product homogeneity and granule strength were developed using the design of experiment approach. Fluidising air velocity and fluidising air temperature were shown to strongly influence the product properties. Optimisation studies showed that strong granules with homogeneous distribution of the active ingredient can be produced at high fluidising air velocity and at high fluidising air temperatures.

Original language	English
Pages (from-to)	173-180
Number of pages	8
Journal	Powder Technology
Volume	272
Early online date	08 Dec 2014
DOIs	https://doi.org/10.1016/j.powtec.2014.11.042
Publication status	Published - Mar 2015

Keywords

granulation
Polyethylene Glycols
homogeneity
fluidised bed hot melt granulation
granule strength

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10.1016/j.powtec.2014.11.042

Investigation of influence of process variables on mechanical properties, size and homogeneity of pharmaceutical granules produced by fluidised hot melt granulation
This is the author’s version of a work that was accepted for publication in Powder Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Powder Technology, vol 272, issue March 2015 doi: 10.1016/j.powtec.2014.11.042.
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Cite this

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title = "Investigation of influence of process variables on mechanical strength, size and homogeneity of pharmaceutical granules produced by fluidised hot melt granulation",

abstract = "The overall aim of the project was to study the influence of process variables on the distribution of a model active pharmaceutical ingredient (API) during fluidised melt granulation of pharmaceutical granules with a view of optimising product characteristics. Granules were produced using common pharmaceutical excipients; lactose monohydrate using poly ethylene glycol (PEG1500) as a meltable binder. Methylene blue was used as a model API. Empirical models relating the process variables to the granules properties such as granule mean size, product homogeneity and granule strength were developed using the design of experiment approach. Fluidising air velocity and fluidising air temperature were shown to strongly influence the product properties. Optimisation studies showed that strong granules with homogeneous distribution of the active ingredient can be produced at high fluidising air velocity and at high fluidising air temperatures.",

keywords = "granulation, Polyethylene Glycols, homogeneity, fluidised bed hot melt granulation, granule strength",

author = "Chirangano Mangwandi and Zainal, {N. A.} and Liu JiangTao and Y. Glocheux and Albadarin, {Ahmad B.}",

year = "2015",

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doi = "10.1016/j.powtec.2014.11.042",

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T1 - Investigation of influence of process variables on mechanical strength, size and homogeneity of pharmaceutical granules produced by fluidised hot melt granulation

AU - Mangwandi, Chirangano

AU - Zainal, N. A.

AU - JiangTao, Liu

AU - Glocheux, Y.

AU - Albadarin, Ahmad B.

PY - 2015/3

Y1 - 2015/3

N2 - The overall aim of the project was to study the influence of process variables on the distribution of a model active pharmaceutical ingredient (API) during fluidised melt granulation of pharmaceutical granules with a view of optimising product characteristics. Granules were produced using common pharmaceutical excipients; lactose monohydrate using poly ethylene glycol (PEG1500) as a meltable binder. Methylene blue was used as a model API. Empirical models relating the process variables to the granules properties such as granule mean size, product homogeneity and granule strength were developed using the design of experiment approach. Fluidising air velocity and fluidising air temperature were shown to strongly influence the product properties. Optimisation studies showed that strong granules with homogeneous distribution of the active ingredient can be produced at high fluidising air velocity and at high fluidising air temperatures.

AB - The overall aim of the project was to study the influence of process variables on the distribution of a model active pharmaceutical ingredient (API) during fluidised melt granulation of pharmaceutical granules with a view of optimising product characteristics. Granules were produced using common pharmaceutical excipients; lactose monohydrate using poly ethylene glycol (PEG1500) as a meltable binder. Methylene blue was used as a model API. Empirical models relating the process variables to the granules properties such as granule mean size, product homogeneity and granule strength were developed using the design of experiment approach. Fluidising air velocity and fluidising air temperature were shown to strongly influence the product properties. Optimisation studies showed that strong granules with homogeneous distribution of the active ingredient can be produced at high fluidising air velocity and at high fluidising air temperatures.

KW - granulation

KW - Polyethylene Glycols

KW - homogeneity

KW - fluidised bed hot melt granulation

KW - granule strength

U2 - 10.1016/j.powtec.2014.11.042

DO - 10.1016/j.powtec.2014.11.042

M3 - Article

AN - SCOPUS:84919624659

SN - 0032-5910

VL - 272

SP - 173

EP - 180

JO - Powder Technology

JF - Powder Technology

ER -

Investigation of influence of process variables on mechanical strength, size and homogeneity of pharmaceutical granules produced by fluidised hot melt granulation

Abstract

Keywords

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