Investigation of methylene blue release from functional polymeric systems using dielectric analysis

Marcos Luciano Bruschi; Mariana Volpato Junqueira; Fernanda Belincanta Borghi-Pangoni; Tao Yu; Gavin Paul Andrews; David Simon Jones

doi:10.2174/1567201814666170602074650

Investigation of methylene blue release from functional polymeric systems using dielectric analysis

Marcos Luciano Bruschi^*, Mariana Volpato Junqueira, Fernanda Belincanta Borghi-Pangoni, Tao Yu, Gavin Paul Andrews, David Simon Jones

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Background: Methylene blue (MB) is a photosensitizer used in photodynamic therapy (PDT) to treat colorectal cancer tumors and leishmaniasis infection. The clinical efficacy of PDT using MB is dependent on the physicochemical characteristics of the formulation. Bioadhesive thermoresponsive systems containing poloxamer 407 and Carbopol 934P have been proposed as platforms for PDT. However, the effect of MB on the physicochemical properties of these platforms is not fully understood, particularly in light of the MB availability.

Objective: The aim of this study was to investigate the dielectric characteristics of functional polymeric systems containing MB and their influence on mucoadhesion and drug release.

Methods: Binary polymeric systems containing different concentrations of poloxamer 407, Carbopol 934P and MB were evaluated as dielectric and mucoadhesive properties, as well as in vitro drug release profile.

Results: MB, temperature and polymeric composition influenced the physicochemical properties of the systems. The presence of MB altered the supramolecular structure of the preparations. The mucoadhesive properties of systems were influenced by MB presence and the formulation with the lowest amount of MB displayed faster release.

Conclusion: The lower MB concentration in the systems displayed better results in terms of ionic mobility and drug release, and is indicative of a suitable clinical performance.

Original language	English
Pages (from-to)	64-76
Number of pages	13
Journal	Current Drug Delivery
Volume	15
Issue number	1
DOIs	https://doi.org/10.2174/1567201814666170602074650
Publication status	Published - 01 Jan 2018

Bibliographical note

Funding Information:
The authors are grateful to the Brazilian agency CAPES (Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior/Coordination for the Improvement of Higher Education), SETI/UGF-Paraná, State University of Maringá (Brazil) and the School of Pharmacy at the Queen’s University of Belfast (Northern Ireland, UK) for supporting the project.

Publisher Copyright:
© 2018 Bentham Science Publishers.

Keywords

Analysis
Biodegradable polymers
Hydrogels
Polymeric drug carrier
Polymeric drug delivery systems
Responsive delivery systems

ASJC Scopus subject areas

Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Investigation of methylene blue release from functional polymeric systems using dielectric analysis",

abstract = "Background: Methylene blue (MB) is a photosensitizer used in photodynamic therapy (PDT) to treat colorectal cancer tumors and leishmaniasis infection. The clinical efficacy of PDT using MB is dependent on the physicochemical characteristics of the formulation. Bioadhesive thermoresponsive systems containing poloxamer 407 and Carbopol 934P have been proposed as platforms for PDT. However, the effect of MB on the physicochemical properties of these platforms is not fully understood, particularly in light of the MB availability. Objective: The aim of this study was to investigate the dielectric characteristics of functional polymeric systems containing MB and their influence on mucoadhesion and drug release. Methods: Binary polymeric systems containing different concentrations of poloxamer 407, Carbopol 934P and MB were evaluated as dielectric and mucoadhesive properties, as well as in vitro drug release profile. Results: MB, temperature and polymeric composition influenced the physicochemical properties of the systems. The presence of MB altered the supramolecular structure of the preparations. The mucoadhesive properties of systems were influenced by MB presence and the formulation with the lowest amount of MB displayed faster release. Conclusion: The lower MB concentration in the systems displayed better results in terms of ionic mobility and drug release, and is indicative of a suitable clinical performance.",

keywords = "Analysis, Biodegradable polymers, Hydrogels, Polymeric drug carrier, Polymeric drug delivery systems, Responsive delivery systems",

author = "Bruschi, {Marcos Luciano} and Junqueira, {Mariana Volpato} and Borghi-Pangoni, {Fernanda Belincanta} and Tao Yu and Andrews, {Gavin Paul} and Jones, {David Simon}",

note = "Funding Information: The authors are grateful to the Brazilian agency CAPES (Coordenac{\~a}o de Aperfei{\c c}oamento de Pessoal de N{\'i}vel Superior/Coordination for the Improvement of Higher Education), SETI/UGF-Paran{\'a}, State University of Maring{\'a} (Brazil) and the School of Pharmacy at the Queen{\textquoteright}s University of Belfast (Northern Ireland, UK) for supporting the project. Publisher Copyright: {\textcopyright} 2018 Bentham Science Publishers.",

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T1 - Investigation of methylene blue release from functional polymeric systems using dielectric analysis

AU - Bruschi, Marcos Luciano

AU - Junqueira, Mariana Volpato

AU - Borghi-Pangoni, Fernanda Belincanta

AU - Yu, Tao

AU - Andrews, Gavin Paul

AU - Jones, David Simon

N1 - Funding Information: The authors are grateful to the Brazilian agency CAPES (Coordenacão de Aperfeiçoamento de Pessoal de Nível Superior/Coordination for the Improvement of Higher Education), SETI/UGF-Paraná, State University of Maringá (Brazil) and the School of Pharmacy at the Queen’s University of Belfast (Northern Ireland, UK) for supporting the project. Publisher Copyright: © 2018 Bentham Science Publishers.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Methylene blue (MB) is a photosensitizer used in photodynamic therapy (PDT) to treat colorectal cancer tumors and leishmaniasis infection. The clinical efficacy of PDT using MB is dependent on the physicochemical characteristics of the formulation. Bioadhesive thermoresponsive systems containing poloxamer 407 and Carbopol 934P have been proposed as platforms for PDT. However, the effect of MB on the physicochemical properties of these platforms is not fully understood, particularly in light of the MB availability. Objective: The aim of this study was to investigate the dielectric characteristics of functional polymeric systems containing MB and their influence on mucoadhesion and drug release. Methods: Binary polymeric systems containing different concentrations of poloxamer 407, Carbopol 934P and MB were evaluated as dielectric and mucoadhesive properties, as well as in vitro drug release profile. Results: MB, temperature and polymeric composition influenced the physicochemical properties of the systems. The presence of MB altered the supramolecular structure of the preparations. The mucoadhesive properties of systems were influenced by MB presence and the formulation with the lowest amount of MB displayed faster release. Conclusion: The lower MB concentration in the systems displayed better results in terms of ionic mobility and drug release, and is indicative of a suitable clinical performance.

AB - Background: Methylene blue (MB) is a photosensitizer used in photodynamic therapy (PDT) to treat colorectal cancer tumors and leishmaniasis infection. The clinical efficacy of PDT using MB is dependent on the physicochemical characteristics of the formulation. Bioadhesive thermoresponsive systems containing poloxamer 407 and Carbopol 934P have been proposed as platforms for PDT. However, the effect of MB on the physicochemical properties of these platforms is not fully understood, particularly in light of the MB availability. Objective: The aim of this study was to investigate the dielectric characteristics of functional polymeric systems containing MB and their influence on mucoadhesion and drug release. Methods: Binary polymeric systems containing different concentrations of poloxamer 407, Carbopol 934P and MB were evaluated as dielectric and mucoadhesive properties, as well as in vitro drug release profile. Results: MB, temperature and polymeric composition influenced the physicochemical properties of the systems. The presence of MB altered the supramolecular structure of the preparations. The mucoadhesive properties of systems were influenced by MB presence and the formulation with the lowest amount of MB displayed faster release. Conclusion: The lower MB concentration in the systems displayed better results in terms of ionic mobility and drug release, and is indicative of a suitable clinical performance.

KW - Analysis

KW - Biodegradable polymers

KW - Hydrogels

KW - Polymeric drug carrier

KW - Polymeric drug delivery systems

KW - Responsive delivery systems

U2 - 10.2174/1567201814666170602074650

DO - 10.2174/1567201814666170602074650

M3 - Article

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AN - SCOPUS:85044363438

SN - 1567-2018

VL - 15

SP - 64

EP - 76

JO - Current Drug Delivery

JF - Current Drug Delivery

IS - 1

ER -

Investigation of methylene blue release from functional polymeric systems using dielectric analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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