Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics Study.

Katherine O'Neill, Judy Bradley, Gokul Lakshmipathy, Ivan Neely, Denise Cosgrove, Kathryn Ferguson nee McDowell, James D. Chalmers, Anthony DeSoyza, Timothy Gatheral, Adam T. Hill, John R Hurst, Michael R Loebinger, Joseph Elborn

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Abstract

05.02 - Monitoring Airway Disease 11549
Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics study.
Bronchiectasis, Lung function testing
K. O'Neill1, G. R. Lakshmipathy1, C. Neely1, D. Cosgrove2, K. Ferguson2, J. D. Chalmers3, A. Desoyza4, T. Gatheral5, A. T. Hill6, J. R. Hurst7, M. R. Loebinger8, J. S. Elborn9, J. M. Bradley101Wellcome-Wolfson Institute for Experimental Medicine, Queen's University - Belfast (United Kingdom), 2Belfast Health and Social Care Trust - Belfast (United Kingdom), 3University of Dundee, College of Medicine - Dundee (United Kingdom), 4Institute of Cellular Medicine, Newcastle University, National Institute of Health Research Biomedical Research Centre - Newcastle (United Kingdom), 5Department of Respiratory Medicine, University Hospitals of Morecambe Bay NHS Foundation Trust - Kendal (United Kingdom), 6Royal Infirmary and University of Edinburgh - Edinburgh (United Kingdom), 7University College London Respiratory, University College London - London (United Kingdom), 8Host Defence Unit, Royal Brompton Hospital, Imperial College London - London (United Kingdom), 9Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast; Host Defence Unit, Royal Brompton Hospital, Imperial College London - London (United Kingdom), 10Clinical Research Facility, Queen’s University - Belfast (United Kingdom)
Background: LCI has good intravisit repeatability with better sensitivity in detecting lung disease on CT scan compared to FEV1 in adults with bronchiectasis (BE) (Rowan et al. 2014). However, the test can be prolonged. Shortened LCI may provide sufficient information on ventilation distribution and reduce test time.Aim:To compare the intravisit repeatability (CV%) of LCI2.5 (standard LCI) and LCI5 (shortened LCI) relationship between FEV1% predicted and LCI2.5 and LCI5.time duration of the triplicate washout for LCI2.5 and LCI5.
Methods: Multiple Breath Nitrogen Washout data (Exhalyzer D) from the first 98 patients across 5 UK centres (November 2015- June 2017) were over-read centrally for quality control. LCI2.5 (LCI at 2.5% N2) and LCI5 (LCI at 5% N2) data were summarised. CV% and duration of tests (minutes) were compared using paired sample t–tests. Pearson correlation were used to assess relationships.Results: Subjects (n=98), M:F 37:61, had a mean age (SD) 64.8 (11.6) years, FEV1% predicted=74.7 (20.9), LCI2.5 =12.6 (3.2) turnovers, LCI5=7.8 (1.6) turnovers. Mean (SD) CV% of LCI2.5 and LCI5 was 3.8 (2.1) and 2.9 (1.8) respectively (p=0.03). Mean (SD) duration (minutes) of LCI .5 and LCI5 washout time was 15.2 (7.8) and 7.8 (3.6) respectively (p<0.001). The correlation (r and p-value) between FEV1% predicted and LCI2.5 and LCI5 was r=-0.56 (p<0.001) and r=-0.56 (p<0.001) respectively.

Conclusions: In this study, LCI5 had reduced variability (CV%), a comparable strength of correlation with FEV1% predicted and a significant time saving compared with LCI2.5. Investigation of LCI5 in BE clinical trials as a surrogate outcome is warranted.
Original languageEnglish
Number of pages2
Publication statusAccepted - 05 Jun 2018
EventEuropean Respiratory Society International Congress 2018: Paris, 2018 - Paris, France, Paris, France
Duration: 15 Sep 201819 Sep 2018

Conference

ConferenceEuropean Respiratory Society International Congress 2018
CountryFrance
CityParis
Period15/09/201819/09/2018

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Lung
Bronchiectasis
Biomedical Research
Medicine
United Kingdom
Pulmonary Medicine
National Institutes of Health (U.S.)
Research
Quality Control
Lung Diseases
Ventilation
Nitrogen
Clinical Trials
Delivery of Health Care

Keywords

  • Bronchiectasis
  • Lung
  • Function
  • Testing

Cite this

O'Neill, K., Bradley, J., Lakshmipathy, G., Neely, I., Cosgrove, D., Ferguson nee McDowell, K., ... Elborn, J. (Accepted/In press). Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics Study.. Abstract from European Respiratory Society International Congress 2018, Paris, France.
O'Neill, Katherine ; Bradley, Judy ; Lakshmipathy, Gokul ; Neely, Ivan ; Cosgrove, Denise ; Ferguson nee McDowell, Kathryn ; Chalmers, James D. ; DeSoyza, Anthony ; Gatheral, Timothy ; Hill, Adam T. ; Hurst, John R ; Loebinger, Michael R ; Elborn, Joseph. / Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics Study. Abstract from European Respiratory Society International Congress 2018, Paris, France.2 p.
@conference{140d43db25f545b88439f02d96132e41,
title = "Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics Study.",
abstract = "05.02 - Monitoring Airway Disease 11549 Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics study.Bronchiectasis, Lung function testingK. O'Neill1, G. R. Lakshmipathy1, C. Neely1, D. Cosgrove2, K. Ferguson2, J. D. Chalmers3, A. Desoyza4, T. Gatheral5, A. T. Hill6, J. R. Hurst7, M. R. Loebinger8, J. S. Elborn9, J. M. Bradley101Wellcome-Wolfson Institute for Experimental Medicine, Queen's University - Belfast (United Kingdom), 2Belfast Health and Social Care Trust - Belfast (United Kingdom), 3University of Dundee, College of Medicine - Dundee (United Kingdom), 4Institute of Cellular Medicine, Newcastle University, National Institute of Health Research Biomedical Research Centre - Newcastle (United Kingdom), 5Department of Respiratory Medicine, University Hospitals of Morecambe Bay NHS Foundation Trust - Kendal (United Kingdom), 6Royal Infirmary and University of Edinburgh - Edinburgh (United Kingdom), 7University College London Respiratory, University College London - London (United Kingdom), 8Host Defence Unit, Royal Brompton Hospital, Imperial College London - London (United Kingdom), 9Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast; Host Defence Unit, Royal Brompton Hospital, Imperial College London - London (United Kingdom), 10Clinical Research Facility, Queen’s University - Belfast (United Kingdom)Background: LCI has good intravisit repeatability with better sensitivity in detecting lung disease on CT scan compared to FEV1 in adults with bronchiectasis (BE) (Rowan et al. 2014). However, the test can be prolonged. Shortened LCI may provide sufficient information on ventilation distribution and reduce test time.Aim:To compare the intravisit repeatability (CV{\%}) of LCI2.5 (standard LCI) and LCI5 (shortened LCI) relationship between FEV1{\%} predicted and LCI2.5 and LCI5.time duration of the triplicate washout for LCI2.5 and LCI5.Methods: Multiple Breath Nitrogen Washout data (Exhalyzer D) from the first 98 patients across 5 UK centres (November 2015- June 2017) were over-read centrally for quality control. LCI2.5 (LCI at 2.5{\%} N2) and LCI5 (LCI at 5{\%} N2) data were summarised. CV{\%} and duration of tests (minutes) were compared using paired sample t–tests. Pearson correlation were used to assess relationships.Results: Subjects (n=98), M:F 37:61, had a mean age (SD) 64.8 (11.6) years, FEV1{\%} predicted=74.7 (20.9), LCI2.5 =12.6 (3.2) turnovers, LCI5=7.8 (1.6) turnovers. Mean (SD) CV{\%} of LCI2.5 and LCI5 was 3.8 (2.1) and 2.9 (1.8) respectively (p=0.03). Mean (SD) duration (minutes) of LCI .5 and LCI5 washout time was 15.2 (7.8) and 7.8 (3.6) respectively (p<0.001). The correlation (r and p-value) between FEV1{\%} predicted and LCI2.5 and LCI5 was r=-0.56 (p<0.001) and r=-0.56 (p<0.001) respectively. Conclusions: In this study, LCI5 had reduced variability (CV{\%}), a comparable strength of correlation with FEV1{\%} predicted and a significant time saving compared with LCI2.5. Investigation of LCI5 in BE clinical trials as a surrogate outcome is warranted.",
keywords = "Bronchiectasis, Lung, Function, Testing",
author = "Katherine O'Neill and Judy Bradley and Gokul Lakshmipathy and Ivan Neely and Denise Cosgrove and {Ferguson nee McDowell}, Kathryn and Chalmers, {James D.} and Anthony DeSoyza and Timothy Gatheral and Hill, {Adam T.} and Hurst, {John R} and Loebinger, {Michael R} and Joseph Elborn",
year = "2018",
month = "6",
day = "5",
language = "English",
note = "European Respiratory Society International Congress 2018 : Paris, 2018 ; Conference date: 15-09-2018 Through 19-09-2018",

}

O'Neill, K, Bradley, J, Lakshmipathy, G, Neely, I, Cosgrove, D, Ferguson nee McDowell, K, Chalmers, JD, DeSoyza, A, Gatheral, T, Hill, AT, Hurst, JR, Loebinger, MR & Elborn, J 2018, 'Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics Study.', European Respiratory Society International Congress 2018, Paris, France, 15/09/2018 - 19/09/2018.

Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics Study. / O'Neill, Katherine; Bradley, Judy; Lakshmipathy, Gokul; Neely, Ivan; Cosgrove, Denise; Ferguson nee McDowell, Kathryn; Chalmers, James D.; DeSoyza, Anthony; Gatheral, Timothy; Hill, Adam T.; Hurst, John R; Loebinger, Michael R; Elborn, Joseph.

2018. Abstract from European Respiratory Society International Congress 2018, Paris, France.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics Study.

AU - O'Neill, Katherine

AU - Bradley, Judy

AU - Lakshmipathy, Gokul

AU - Neely, Ivan

AU - Cosgrove, Denise

AU - Ferguson nee McDowell, Kathryn

AU - Chalmers, James D.

AU - DeSoyza, Anthony

AU - Gatheral, Timothy

AU - Hill, Adam T.

AU - Hurst, John R

AU - Loebinger, Michael R

AU - Elborn, Joseph

PY - 2018/6/5

Y1 - 2018/6/5

N2 - 05.02 - Monitoring Airway Disease 11549 Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics study.Bronchiectasis, Lung function testingK. O'Neill1, G. R. Lakshmipathy1, C. Neely1, D. Cosgrove2, K. Ferguson2, J. D. Chalmers3, A. Desoyza4, T. Gatheral5, A. T. Hill6, J. R. Hurst7, M. R. Loebinger8, J. S. Elborn9, J. M. Bradley101Wellcome-Wolfson Institute for Experimental Medicine, Queen's University - Belfast (United Kingdom), 2Belfast Health and Social Care Trust - Belfast (United Kingdom), 3University of Dundee, College of Medicine - Dundee (United Kingdom), 4Institute of Cellular Medicine, Newcastle University, National Institute of Health Research Biomedical Research Centre - Newcastle (United Kingdom), 5Department of Respiratory Medicine, University Hospitals of Morecambe Bay NHS Foundation Trust - Kendal (United Kingdom), 6Royal Infirmary and University of Edinburgh - Edinburgh (United Kingdom), 7University College London Respiratory, University College London - London (United Kingdom), 8Host Defence Unit, Royal Brompton Hospital, Imperial College London - London (United Kingdom), 9Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast; Host Defence Unit, Royal Brompton Hospital, Imperial College London - London (United Kingdom), 10Clinical Research Facility, Queen’s University - Belfast (United Kingdom)Background: LCI has good intravisit repeatability with better sensitivity in detecting lung disease on CT scan compared to FEV1 in adults with bronchiectasis (BE) (Rowan et al. 2014). However, the test can be prolonged. Shortened LCI may provide sufficient information on ventilation distribution and reduce test time.Aim:To compare the intravisit repeatability (CV%) of LCI2.5 (standard LCI) and LCI5 (shortened LCI) relationship between FEV1% predicted and LCI2.5 and LCI5.time duration of the triplicate washout for LCI2.5 and LCI5.Methods: Multiple Breath Nitrogen Washout data (Exhalyzer D) from the first 98 patients across 5 UK centres (November 2015- June 2017) were over-read centrally for quality control. LCI2.5 (LCI at 2.5% N2) and LCI5 (LCI at 5% N2) data were summarised. CV% and duration of tests (minutes) were compared using paired sample t–tests. Pearson correlation were used to assess relationships.Results: Subjects (n=98), M:F 37:61, had a mean age (SD) 64.8 (11.6) years, FEV1% predicted=74.7 (20.9), LCI2.5 =12.6 (3.2) turnovers, LCI5=7.8 (1.6) turnovers. Mean (SD) CV% of LCI2.5 and LCI5 was 3.8 (2.1) and 2.9 (1.8) respectively (p=0.03). Mean (SD) duration (minutes) of LCI .5 and LCI5 washout time was 15.2 (7.8) and 7.8 (3.6) respectively (p<0.001). The correlation (r and p-value) between FEV1% predicted and LCI2.5 and LCI5 was r=-0.56 (p<0.001) and r=-0.56 (p<0.001) respectively. Conclusions: In this study, LCI5 had reduced variability (CV%), a comparable strength of correlation with FEV1% predicted and a significant time saving compared with LCI2.5. Investigation of LCI5 in BE clinical trials as a surrogate outcome is warranted.

AB - 05.02 - Monitoring Airway Disease 11549 Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics study.Bronchiectasis, Lung function testingK. O'Neill1, G. R. Lakshmipathy1, C. Neely1, D. Cosgrove2, K. Ferguson2, J. D. Chalmers3, A. Desoyza4, T. Gatheral5, A. T. Hill6, J. R. Hurst7, M. R. Loebinger8, J. S. Elborn9, J. M. Bradley101Wellcome-Wolfson Institute for Experimental Medicine, Queen's University - Belfast (United Kingdom), 2Belfast Health and Social Care Trust - Belfast (United Kingdom), 3University of Dundee, College of Medicine - Dundee (United Kingdom), 4Institute of Cellular Medicine, Newcastle University, National Institute of Health Research Biomedical Research Centre - Newcastle (United Kingdom), 5Department of Respiratory Medicine, University Hospitals of Morecambe Bay NHS Foundation Trust - Kendal (United Kingdom), 6Royal Infirmary and University of Edinburgh - Edinburgh (United Kingdom), 7University College London Respiratory, University College London - London (United Kingdom), 8Host Defence Unit, Royal Brompton Hospital, Imperial College London - London (United Kingdom), 9Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast; Host Defence Unit, Royal Brompton Hospital, Imperial College London - London (United Kingdom), 10Clinical Research Facility, Queen’s University - Belfast (United Kingdom)Background: LCI has good intravisit repeatability with better sensitivity in detecting lung disease on CT scan compared to FEV1 in adults with bronchiectasis (BE) (Rowan et al. 2014). However, the test can be prolonged. Shortened LCI may provide sufficient information on ventilation distribution and reduce test time.Aim:To compare the intravisit repeatability (CV%) of LCI2.5 (standard LCI) and LCI5 (shortened LCI) relationship between FEV1% predicted and LCI2.5 and LCI5.time duration of the triplicate washout for LCI2.5 and LCI5.Methods: Multiple Breath Nitrogen Washout data (Exhalyzer D) from the first 98 patients across 5 UK centres (November 2015- June 2017) were over-read centrally for quality control. LCI2.5 (LCI at 2.5% N2) and LCI5 (LCI at 5% N2) data were summarised. CV% and duration of tests (minutes) were compared using paired sample t–tests. Pearson correlation were used to assess relationships.Results: Subjects (n=98), M:F 37:61, had a mean age (SD) 64.8 (11.6) years, FEV1% predicted=74.7 (20.9), LCI2.5 =12.6 (3.2) turnovers, LCI5=7.8 (1.6) turnovers. Mean (SD) CV% of LCI2.5 and LCI5 was 3.8 (2.1) and 2.9 (1.8) respectively (p=0.03). Mean (SD) duration (minutes) of LCI .5 and LCI5 washout time was 15.2 (7.8) and 7.8 (3.6) respectively (p<0.001). The correlation (r and p-value) between FEV1% predicted and LCI2.5 and LCI5 was r=-0.56 (p<0.001) and r=-0.56 (p<0.001) respectively. Conclusions: In this study, LCI5 had reduced variability (CV%), a comparable strength of correlation with FEV1% predicted and a significant time saving compared with LCI2.5. Investigation of LCI5 in BE clinical trials as a surrogate outcome is warranted.

KW - Bronchiectasis

KW - Lung

KW - Function

KW - Testing

M3 - Abstract

ER -

O'Neill K, Bradley J, Lakshmipathy G, Neely I, Cosgrove D, Ferguson nee McDowell K et al. Investigation of shortened lung clearance index (LCI) in the Bronch-UK Clinimetrics Study.. 2018. Abstract from European Respiratory Society International Congress 2018, Paris, France.