Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus

Amy Jayne McKnight, K.A. Pettigrew, Christopher Patterson, J. Kilner, D.M. Sadlier, A.P. Maxwell

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aims Diabetic nephropathy is a leading cause of end-stage renal disease. The transforming growth factor beta-bone morphogenic protein (BMP) pathway is implicated in the pathogenesis of diabetic nephropathy. The BMP2, BMP4 and BMP7 genes are located near linkage peaks for renal dysfunction, and we hypothesize that genetic polymorphisms in these biological and positional candidate genes may be risk factors for diabetic kidney disease.
Original languageEnglish
Pages (from-to)624-630
Number of pages7
JournalDiabetic Medicine
Volume27
Issue number6
DOIs
Publication statusPublished - Jun 2010

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

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