Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus

Amy Jayne McKnight; K.A. Pettigrew; Christopher Patterson; J. Kilner; D.M. Sadlier; A.P. Maxwell

doi:10.1111/j.1464-5491.2010.02976.x

Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus

Amy Jayne McKnight, K.A. Pettigrew, Christopher Patterson, J. Kilner, D.M. Sadlier, A.P. Maxwell

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Aims Diabetic nephropathy is a leading cause of end-stage renal disease. The transforming growth factor beta-bone morphogenic protein (BMP) pathway is implicated in the pathogenesis of diabetic nephropathy. The BMP2, BMP4 and BMP7 genes are located near linkage peaks for renal dysfunction, and we hypothesize that genetic polymorphisms in these biological and positional candidate genes may be risk factors for diabetic kidney disease.

Original language	English
Pages (from-to)	624-630
Number of pages	7
Journal	Diabetic Medicine
Volume	27
Issue number	6
DOIs	https://doi.org/10.1111/j.1464-5491.2010.02976.x
Publication status	Published - Jun 2010

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Internal Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1464-5491.2010.02976.x

Cite this

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abstract = "Aims Diabetic nephropathy is a leading cause of end-stage renal disease. The transforming growth factor beta-bone morphogenic protein (BMP) pathway is implicated in the pathogenesis of diabetic nephropathy. The BMP2, BMP4 and BMP7 genes are located near linkage peaks for renal dysfunction, and we hypothesize that genetic polymorphisms in these biological and positional candidate genes may be risk factors for diabetic kidney disease.",

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AU - McKnight, Amy Jayne

AU - Pettigrew, K.A.

AU - Patterson, Christopher

AU - Kilner, J.

AU - Sadlier, D.M.

AU - Maxwell, A.P.

PY - 2010/6

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N2 - Aims Diabetic nephropathy is a leading cause of end-stage renal disease. The transforming growth factor beta-bone morphogenic protein (BMP) pathway is implicated in the pathogenesis of diabetic nephropathy. The BMP2, BMP4 and BMP7 genes are located near linkage peaks for renal dysfunction, and we hypothesize that genetic polymorphisms in these biological and positional candidate genes may be risk factors for diabetic kidney disease.

AB - Aims Diabetic nephropathy is a leading cause of end-stage renal disease. The transforming growth factor beta-bone morphogenic protein (BMP) pathway is implicated in the pathogenesis of diabetic nephropathy. The BMP2, BMP4 and BMP7 genes are located near linkage peaks for renal dysfunction, and we hypothesize that genetic polymorphisms in these biological and positional candidate genes may be risk factors for diabetic kidney disease.

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Investigation of the association of BMP gene variants with nephropathy in Type 1 diabetes mellitus

Abstract

ASJC Scopus subject areas

UN SDGs

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