Self-consolidating concrete (SCC) is designed to exhibit high deformability and moderate viscosity to maintain homogeneity and adequate stability to fill the formwork, and encapsulate the reinforcement without any mechanical vibration. Any concrete should have high impermeability and low chloride diffusion to reduce the risk of corrosion and enhance service life. In this study, the effect of the replacement content of cement by supplementary cementing materials (SCM) and fillers. Limestone powder (LSP) replacement of 15% to 30%, ground granulated blastfurnace slag (GGBS) of 40% to 60%, and pulverized fly ash (PFA) of 20% to 35% are evaluated on the durability of SCC of grade C40/50. Fresh concrete properties and development of compressive strength were also evaluated. For the durability performance, all mixtures were tested at 28 days for the air permeability, water permeability, sorptivity, and chloride diffusion which were assessed by Autoclam, and Permit tests. The chloride migration coefficient was dependent on the type SCM and filler in use. The most durable SCC mixture, taking into consideration overall properties, was found to be the one containing 20% PFA, which showed low capillary water absorption, water and air permeation, and lower ionic diffusivity in comparison to the other mixtures. In general, SCC mixtures containing GGBS exhibited inferior performance regarding air and water permeability and sorptivity, but had satisfactory chloride resistance. SCC with 50% of GGBS demonstrates the lowest chloride diffusivity.