Abstract
Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.
Original language | English |
---|---|
Article number | 201703 |
Number of pages | 10 |
Journal | Royal Society Open Science |
Volume | 8 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2021 |
Keywords
- dinucleotides
- mechanochemistry
- organophosphorus