Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry

C. Johnston, C. Hardacre, M. E. Migaud

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, the facilitation of mechanochemical reactions through the improved mixing of solid reagents, and low hydrolytic product formation.
Original languageEnglish
JournalRoyal Society Open Science
Volume8
Issue number3
DOIs
Publication statusEarly online date - 31 Mar 2021

Keywords

  • dinucleotides
  • mechanochemistry
  • organophosphorus

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