Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction

Y.H. Looi; David Grieve; A. Siva; S.J. Walker; N. Anilkumar; A.C. Cave; M. Marber; M.J. Monaghan; A.M. Shah

doi:10.1161/HYPERTENSIONAHA.107.101980

Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction

Y.H. Looi, David Grieve, A. Siva, S.J. Walker, N. Anilkumar, A.C. Cave, M. Marber, M.J. Monaghan, A.M. Shah

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Abstract

Oxidative stress plays an important role in the development of cardiac remodeling after myocardial infarction (MI), but the sources of oxidative stress remain unclear. We investigated the role of Nox2-containing reduced nicotinamide-adenine dinucleotide phosphate oxidase in the development of cardiac remodeling after MI. Adult Nox2(-/-) and matched wild-type (WT) mice were subjected to coronary artery ligation and studied 4 weeks later. Infarct size after MI was similar in Nox2(-/-) and WT mice. Nox2(-/-) mice exhibited significantly less left ventricular (LV) cavity dilatation and dysfunction after MI than WT mice (eg, echocardiographic LV end-diastolic volume: 75.7+/-5.8 versus 112.4+/-12.3 microL; ejection fraction: 41.6+/-3.7 versus 32.9+/-3.2%; both P

Original language	English
Pages (from-to)	319-325
Number of pages	7
Journal	Hypertension
Volume	51
Issue number	2
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.107.101980
Publication status	Published - Feb 2008

ASJC Scopus subject areas

Internal Medicine

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10.1161/HYPERTENSIONAHA.107.101980

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title = "Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction",

abstract = "Oxidative stress plays an important role in the development of cardiac remodeling after myocardial infarction (MI), but the sources of oxidative stress remain unclear. We investigated the role of Nox2-containing reduced nicotinamide-adenine dinucleotide phosphate oxidase in the development of cardiac remodeling after MI. Adult Nox2(-/-) and matched wild-type (WT) mice were subjected to coronary artery ligation and studied 4 weeks later. Infarct size after MI was similar in Nox2(-/-) and WT mice. Nox2(-/-) mice exhibited significantly less left ventricular (LV) cavity dilatation and dysfunction after MI than WT mice (eg, echocardiographic LV end-diastolic volume: 75.7+/-5.8 versus 112.4+/-12.3 microL; ejection fraction: 41.6+/-3.7 versus 32.9+/-3.2%; both P",

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AU - Looi, Y.H.

AU - Grieve, David

AU - Siva, A.

AU - Walker, S.J.

AU - Anilkumar, N.

AU - Cave, A.C.

AU - Marber, M.

AU - Monaghan, M.J.

AU - Shah, A.M.

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Involvement of Nox2 NADPH oxidase in adverse cardiac remodeling after myocardial infarction

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