Abstract
iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine
tumor necrosis factor– (TNF-) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling,
Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in
hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.
Original language | English |
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Article number | eaaz0444 |
Number of pages | 2 |
Journal | Science Signaling |
Volume | 12 |
Issue number | 605 |
DOIs | |
Publication status | Published - 29 Oct 2019 |