Abstract
iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine
tumor necrosis factor– (TNF-) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling,
Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in
hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.
| Original language | English |
|---|---|
| Article number | eaaz0444 |
| Number of pages | 2 |
| Journal | Science Signaling |
| Volume | 12 |
| Issue number | 605 |
| DOIs | |
| Publication status | Published - 29 Oct 2019 |