iRhom2 and TNF: Partners or enemies?

Marina Badenes, Colin Adrain

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
225 Downloads (Pure)


iRhom2 is an essential cofactor for ADAM17, the metalloprotease that sheds both the proinflammatory cytokine tumor necrosis factor– (TNF-) and TNF receptors (TNFRs) from the cell surface. In this issue of Science Signaling, Sundaram et al. demonstrate a protective role for iRhom2 in promoting ADAM17-mediated shedding of TNFRs in hepatic stellate cells, which reduces TNFR signaling and liver fibrosis in response to injury.
Original languageEnglish
Article numbereaaz0444
Number of pages2
JournalScience Signaling
Issue number605
Publication statusPublished - 29 Oct 2019


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