The Bragg Peak is a unique characteristic of ion beams which makes their use beneficial in cancer treatment as it allows the majority of dose deposition to be localised in a precise volume. The use of a laser system for particle acceleration is currently investigated as a potential alternative to the conventional RF accelerators currently used for hadrontherapy. The biological response of cells irradiated by high dose-rate laser-driven ions is currently being explored in this context. The experiment reported here was carried out as part of the A-SAIL project, a UK-wide collaboration aiming to develop innovative techniques for accelerating ions for future clinical applications. In this contest, a radiobiological experiment was carried out on the pico2000 laser beamline at LULI-Ecole Polytechnique using an energetically spread, laser-accelerated proton beam. This paper will discuss the arrangement used in the experiment, and the techniques employed for an accurate estimation of the dose deposited, supported by Monte Carlo simulations of the particle propagation through the irradiation system.
Polin, K., Doria, D., Romagnani, L., Chaudhary, P., Cirrone, G. A. P., Maiorino, C., Milluzzo, G., Petringa, G., Romano, F., Schettino, G., Scuderi, V., Prise, K., & Borghesi, M. (2019). Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons. Journal of Instrumentation, 14(10), [C10015]. https://doi.org/10.1088/1748-0221/14/10/C10015