Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons

K. Polin; D. Doria; L. Romagnani; P. Chaudhary; G A P Cirrone; Carla Maiorino; Giuliana Milluzzo; G. Petringa; Francesco Romano; Giuseppe Schettino; V. Scuderi; Kevin Prise; Marco Borghesi

doi:10.1088/1748-0221/14/10/C10015

Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons

K. Polin, D. Doria, L. Romagnani, P. Chaudhary, G A P Cirrone, Carla Maiorino, Giuliana Milluzzo, G. Petringa, Francesco Romano, Giuseppe Schettino, V. Scuderi, Kevin Prise, Marco Borghesi

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Abstract

The Bragg Peak is a unique characteristic of ion beams which makes their use beneficial in cancer treatment as it allows the majority of dose deposition to be localised in a precise volume. The use of a laser system for particle acceleration is currently investigated as a potential alternative to the conventional RF accelerators currently used for hadrontherapy. The biological response of cells irradiated by high dose-rate laser-driven ions is currently being explored in this context. The experiment reported here was carried out as part of the A-SAIL project, a UK-wide collaboration aiming to develop innovative techniques for accelerating ions for future clinical applications. In this contest, a radiobiological experiment was carried out on the pico2000 laser beamline at LULI-Ecole Polytechnique using an energetically spread, laser-accelerated proton beam. This paper will discuss the arrangement used in the experiment, and the techniques employed for an accurate estimation of the dose deposited, supported by Monte Carlo simulations of the particle propagation through the irradiation system.

Original language	English
Article number	C10015
Journal	Journal of Instrumentation
Volume	14
Issue number	10
DOIs	https://doi.org/10.1088/1748-0221/14/10/C10015 https://doi.org/10.1088/1748-0221/14/10/C10015
Publication status	Published - 10 Oct 2019

Keywords

Ion sources (positive ions, negative ions, electron cyclotron resonance (ECR), electron beam (EBIS))
Lasers; Radiation damage evaluation methods

ASJC Scopus subject areas

Mathematical Physics
Instrumentation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1088/1748-0221/14/10/C10015Licence: Unspecified
10.1088/1748-0221/14/10/C10015

Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons
Copyright 2019 IOP. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 1.1 MBLicence: Unspecified

Cite this

Polin, K., Doria, D., Romagnani, L., Chaudhary, P., Cirrone, G. A. P., Maiorino, C., Milluzzo, G., Petringa, G., Romano, F., Schettino, G., Scuderi, V., Prise, K., & Borghesi, M. (2019). Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons. Journal of Instrumentation, 14(10), Article C10015. https://doi.org/10.1088/1748-0221/14/10/C10015, https://doi.org/10.1088/1748-0221/14/10/C10015

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abstract = "The Bragg Peak is a unique characteristic of ion beams which makes their use beneficial in cancer treatment as it allows the majority of dose deposition to be localised in a precise volume. The use of a laser system for particle acceleration is currently investigated as a potential alternative to the conventional RF accelerators currently used for hadrontherapy. The biological response of cells irradiated by high dose-rate laser-driven ions is currently being explored in this context. The experiment reported here was carried out as part of the A-SAIL project, a UK-wide collaboration aiming to develop innovative techniques for accelerating ions for future clinical applications. In this contest, a radiobiological experiment was carried out on the pico2000 laser beamline at LULI-Ecole Polytechnique using an energetically spread, laser-accelerated proton beam. This paper will discuss the arrangement used in the experiment, and the techniques employed for an accurate estimation of the dose deposited, supported by Monte Carlo simulations of the particle propagation through the irradiation system.",

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author = "K. Polin and D. Doria and L. Romagnani and P. Chaudhary and Cirrone, {G A P} and Carla Maiorino and Giuliana Milluzzo and G. Petringa and Francesco Romano and Giuseppe Schettino and V. Scuderi and Kevin Prise and Marco Borghesi",

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Polin, K, Doria, D, Romagnani, L, Chaudhary, P, Cirrone, GAP, Maiorino, C, Milluzzo, G, Petringa, G, Romano, F, Schettino, G, Scuderi, V, Prise, K & Borghesi, M 2019, 'Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons', Journal of Instrumentation, vol. 14, no. 10, C10015. https://doi.org/10.1088/1748-0221/14/10/C10015, https://doi.org/10.1088/1748-0221/14/10/C10015

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AU - Polin, K.

AU - Doria, D.

AU - Romagnani, L.

AU - Chaudhary, P.

AU - Cirrone, G A P

AU - Maiorino, Carla

AU - Milluzzo, Giuliana

AU - Petringa, G.

AU - Romano, Francesco

AU - Schettino, Giuseppe

AU - Scuderi, V.

AU - Prise, Kevin

AU - Borghesi, Marco

PY - 2019/10/10

Y1 - 2019/10/10

N2 - The Bragg Peak is a unique characteristic of ion beams which makes their use beneficial in cancer treatment as it allows the majority of dose deposition to be localised in a precise volume. The use of a laser system for particle acceleration is currently investigated as a potential alternative to the conventional RF accelerators currently used for hadrontherapy. The biological response of cells irradiated by high dose-rate laser-driven ions is currently being explored in this context. The experiment reported here was carried out as part of the A-SAIL project, a UK-wide collaboration aiming to develop innovative techniques for accelerating ions for future clinical applications. In this contest, a radiobiological experiment was carried out on the pico2000 laser beamline at LULI-Ecole Polytechnique using an energetically spread, laser-accelerated proton beam. This paper will discuss the arrangement used in the experiment, and the techniques employed for an accurate estimation of the dose deposited, supported by Monte Carlo simulations of the particle propagation through the irradiation system.

AB - The Bragg Peak is a unique characteristic of ion beams which makes their use beneficial in cancer treatment as it allows the majority of dose deposition to be localised in a precise volume. The use of a laser system for particle acceleration is currently investigated as a potential alternative to the conventional RF accelerators currently used for hadrontherapy. The biological response of cells irradiated by high dose-rate laser-driven ions is currently being explored in this context. The experiment reported here was carried out as part of the A-SAIL project, a UK-wide collaboration aiming to develop innovative techniques for accelerating ions for future clinical applications. In this contest, a radiobiological experiment was carried out on the pico2000 laser beamline at LULI-Ecole Polytechnique using an energetically spread, laser-accelerated proton beam. This paper will discuss the arrangement used in the experiment, and the techniques employed for an accurate estimation of the dose deposited, supported by Monte Carlo simulations of the particle propagation through the irradiation system.

KW - Ion sources (positive ions, negative ions, electron cyclotron resonance (ECR), electron beam (EBIS))

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Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Ion dosimetry for radiobiology experiments employing laser-accelerated beams

Pre-clinical evaluation of lethal and sublethal DNA damage in human cell cultures by ultrashort pulse and ultra-high dose rate laser accelerated protons

Cite this

Irradiation and dosimetry arrangement for a radiobiological experiment employing laser-accelerated protons

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Student theses

Ion dosimetry for radiobiology experiments employing laser-accelerated beams

Pre-clinical evaluation of lethal and sublethal DNA damage in human cell cultures by ultrashort pulse and ultra-high dose rate laser accelerated protons

Cite this