Background: The histidine triad nucleotide-binding protein 1, HINT1, hydrolyzes adenosine 5'monophosphoramidate substrates such as AMP-morpholidate. The human HINT1 gene is located on chromosome 5q31.2, a region implicated in linkage studies of schizophrenia. HINT1 had been shown to have different expression in postmortem brains between schizophrenia patients and unaffected controls. It was also found to be associated with the dysregulation of postsynaptic dopamine transmission, thus suggesting a potential role in several neuropsychiatric diseases.
ASJC Scopus subject areas
- Psychiatry and Mental health
- Biological Psychiatry
Chen, Q., Wang, X., O'Neill, F., Walsh, D., Kendler, K. S., & Chen, X. N. (2008). Is the histidine triad nucleotide-binding protein 1 (HINT1) gene a candidate for schizophrenia? Schizophrenia research, 106(2-3), 200-207. https://doi.org/10.1016/j.schres.2008.08.006