JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer

Yi Fang Lee, Lance David Miller, Xiu Bin Chan, Michael A Black, Brendan Pang, Chee Wee Ong, Manuel Salto-Tellez, Edison T Liu, Kartiki V Desai

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Abstract

We developed an analytic strategy that correlates gene expression and clinical outcomes as a means to identify novel candidate oncogenes operative in breast cancer. This analysis, followed by functional characterization, resulted in the identification of Jumonji Domain Containing 6 (JMJD6) protein as a novel driver of oncogenic properties in breast cancer.
Original languageEnglish
Pages (from-to)R85
JournalBreast Cancer Research
Volume14
Issue number3
DOIs
Publication statusPublished - 2012

Keywords

  • Cell Movement
  • Disease-Free Survival
  • Jumonji Domain-Containing Histone Demethylases
  • Humans
  • Prognosis
  • Breast Neoplasms
  • Cell Line, Tumor
  • RNA, Small Interfering
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic
  • Transforming Growth Factor beta2
  • MCF-7 Cells
  • RNA Interference
  • Tumor Markers, Biological
  • Cyclin E
  • Female

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    Lee, Y. F., Miller, L. D., Chan, X. B., Black, M. A., Pang, B., Ong, C. W., Salto-Tellez, M., Liu, E. T., & Desai, K. V. (2012). JMJD6 is a driver of cellular proliferation and motility and a marker of poor prognosis in breast cancer. Breast Cancer Research, 14(3), R85. https://doi.org/10.1186/bcr3200