Kaposi's sarcoma in the Gambia, West Africa is less frequent in human immunodeficiency virus type 2 than in human immunodeficiency virus type 1 infection despite a high prevalence of human herpesvirus 8

K Ariyoshi, M Schim van der Loeff, P Cook, D Whitby, T Corrah, S Jaffar, F Cham, S Sabally, D O'Donovan, R A Weiss, T F Schulz, H Whittle

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)

Abstract

OBJECTIVES: To investigate the distribution of Kaposi's sarcoma (KS) cases in patients with human immunodeficiency virus types 1 and 2 (HIV-1 and HIV-2) infection in the Gambia; to document the prevalence of human herpesvirus 8 (HHV-8) infection in various population groups in the Gambia.

STUDY DESIGN/METHODS: A retrospective analysis of KS cases in hospital records at the Medical Research Council (MRC) hospital was performed, along with a cross-sectional survey of HHV-8 prevalence in hospital-based and community-based study population with polymerase chain reaction (PCR) and serologic assays.

RESULTS: After adjusting for gender and CD% at the first visit, HIV-1-positive patients were 12.4 times more likely to have KS than were HIV-2-positive patients. The prevalence of antibodies to HHV-8 and the HHV-8 genome was high in both HIV-1-positive and HIV-2-positive patients without KS. The prevalence of antibodies was also high in pregnant women who were HIV-1-positive, HIV-2-positive, or HIV-negative (73%, 83%, and 79%, respectively).

CONCLUSIONS: HHV-8 infection is widespread in the Gambia. In addition to immunosuppression and HHV-8 infection, other cofactors specifically related to HIV-1 rather than HIV-2 appear to be involved in the development of KS.

Original languageEnglish
Pages (from-to)193-9
Number of pages7
JournalJournal of human virology
Volume1
Issue number3
Publication statusPublished - 09 Apr 1999

Keywords

  • AIDS-Related Opportunistic Infections/epidemiology
  • Adolescent
  • Adult
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Gambia/epidemiology
  • HIV-1
  • HIV-2
  • Herpesvirus 8, Human
  • Humans
  • Male
  • Middle Aged
  • Polymerase Chain Reaction
  • Pregnancy
  • Prevalence
  • Retrospective Studies
  • Risk Factors
  • Sarcoma, Kaposi/epidemiology

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