Abstract
Singles only: DNA sequences can be induced to spontaneously adsorb to the surfaces of Ag colloids through their nucleotide side chains (see picture). The SERS spectra of these nonspecifically bound strands are sufficiently reproducible that they can be used to identify single-base mismatches in short (25-mer and 23-mer) strands. Subtracting the spectra of different DNA sequences results in difference spectra that contain features corresponding to the exchanged nucleotides.
| Original language | English |
|---|---|
| Pages (from-to) | 9058-9061 |
| Number of pages | 4 |
| Journal | Angewandte Chemie International Edition |
| Volume | 50 |
| Issue number | 39 |
| Early online date | 19 Jul 2011 |
| DOIs | |
| Publication status | Published - 19 Sept 2011 |
Keywords
- DNA
- nanomaterials
- nucleotides
- RNA
- SERS
ASJC Scopus subject areas
- General Chemistry
- Catalysis