Lack of Association Between Haptoglobin Phenotype and Cystic Fibrosis Outcomes

Michal Shteinberg, Joseph Rivlin, Michal Gur, Muriel Konopnicki, Nili Stein, Michael M Tunney, J Stuart Elborn, Damian G. Downey, Elinor Johnston, Hadar Shalom, Andrew Levy

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Haptoglobin (Hp), a heme-Iron chelator, has different isoforms which are associated with variable tendency toward infections: Hp 1-1, Hp 2-1, and Hp 2-2. Cystic fibrosis (CF) outcomes are variable and influenced by genetic and environmental factors. The aim of this study was to determine whether Hp phenotype influenced disease severity in CF. One hundred forty-two CF patients from two centers were analyzed for Haptoglobin phenotype using gel electrophoresis of hemoglobin enriched serum. Clinical and microbiological data including bacterial colonization status, lung function, presence of CF-related diabetes and liver disease, rate of exacerbation, and mortality were compared between Hp phenotype groups. We found a trend toward less mucoid PA among Hp 2-2 (20.4 %) compared with Hp 1-1 and Hp 2-1 individuals (33.3 %), p = 0.317. Hp 2-2 individuals also had less antibiotic courses, and lower inflammatory markers without statistical significance. Haptoglobin phenotype is unlikely to be an important modifier of CF phenotype.

Original languageEnglish
Pages (from-to)1017-1021
Number of pages5
JournalLung
Volume193
Issue number6
Early online date07 Sep 2015
DOIs
Publication statusPublished - Dec 2015

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